Eimeria tenella: B-cell epitope mapping following primary and secondary infections.

Abstract

Immunisation against coccidiosis has become more reliable and effective with improved administration techniques for new vaccines. On the other hand, an ideal coccidial vaccine should contain both B- and T-cell immunogenic epitopes. Fine specificity of B-cell epitopes recognised by antibodies prepared following primary and secondary infections with Eimeria tenella were studied using "PepScan" techniques. Mapping of B-cell epitopes within an antigenic sequence from E. tenella showed that four distinct types of epitopes were recognised by the host immune system during the primary and secondary infections with the parasite. These observations demonstrated that new epitopes are also involved in induction of antibody responses following the secondary infection.

• Authors: Alireza Talebi, Grace Mulcahy
• Journal: Experimental parasitology (Exp Parasitol) Vol. 113 Issue 4 Pg. 235-8 (Aug 2006) ISSN: 0014-4894 [Print] United States
• PMID: 16510143 (Publication Type: Journal Article)

Chemical References

• Antibodies, Protozoan
• Antigens, Protozoan
• Epitopes, B-Lymphocyte

Topics

• Animals
• Antibodies, Protozoan (biosynthesis, blood)
• Antibody Specificity
• Antigens, Protozoan (immunology)
• B-Lymphocytes (immunology)
• Chickens (parasitology)
• Coccidiosis (immunology, veterinary)
• Eimeria tenella (immunology)
• Epitope Mapping (veterinary)
• Epitopes, B-Lymphocyte (immunology)
• Oocysts (immunology)
• Poultry Diseases (immunology, parasitology)
• Recurrence
• Specific Pathogen-Free Organisms