Two-year prospective study of the humoral immune response of patients with severe acute respiratory syndrome.

Abstract

In a cohort study of 56 convalescent patients with severe acute respiratory syndrome (SARS), titers of immunoglobulin G (IgG) antibodies and neutralizing antibodies (NAbs) against SARS-associated coronavirus were assessed at regular intervals (at 1, 4, 7, 10, 16, and 24 months after the onset of disease) by use of enzyme-linked immunosorbent assay and neutralization assay. IgG antibody and NAb titers were highly correlated, peaking at month 4 after the onset of disease and decreasing thereafter. IgG antibodies remained detectable in all patients until month 16, and they became undetectable in 11.8% of patients at month 24. The finding that NAbs remained detectable throughout follow-up is reassuring in terms of protection provided against reinfection; however, NAb titers decreased markedly after month 16.

• Authors: Wei Liu, Arnaud Fontanet, Pan-He Zhang, Lin Zhan, Zhong-Tao Xin, Laurence Baril, Fang Tang, Hui Lv, Wu-Chun Cao
• Journal: The Journal of infectious diseases (J Infect Dis) Vol. 193 Issue 6 Pg. 792-5 (Mar 15 2006) ISSN: 0022-1899 [Print] United States
• PMID: 16479513 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Viral
• Immunoglobulin G

Topics

• Antibodies, Viral (blood, immunology)
• Antibody Formation
• Cohort Studies
• Humans
• Immunoglobulin G (blood)
• Neutralization Tests
• Prospective Studies
• Severe acute respiratory syndrome-related coronavirus (immunology)
• Severe Acute Respiratory Syndrome (immunology, virology)