Severe Acute Respiratory Syndrome

A viral disorder characterized by high FEVER, dry COUGH, shortness of breath (DYSPNEA) or breathing difficulties, and atypical PNEUMONIA. A virus in the genus CORONAVIRUS is the suspected agent.

Also Known As:

Networked: 1024 relevant articles (30 outcomes, 81 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Infection
2.	Respiratory Insufficiency (Respiratory Failure)
3.	Human Influenza (Influenza)
4.	Respiratory Tract Infections (Respiratory Tract Infection)
5.	Shock

Experts

1.	Baker, Susan C: 22 articles (05/2015 - 12/2004)
2.	Tan, Yee-Joo: 19 articles (04/2013 - 03/2004)
3.	He, Yuxian: 19 articles (12/2011 - 09/2004)
4.	Mesecar, Andrew D: 18 articles (05/2015 - 11/2005)
5.	Jiang, Shibo: 18 articles (01/2014 - 09/2004)
6.	Baric, Ralph S: 17 articles (04/2015 - 10/2003)
7.	Enjuanes, Luis: 16 articles (11/2015 - 10/2004)
8.	Yuen, Kwok-Yung: 15 articles (12/2013 - 06/2004)
9.	Peiris, J S Malik: 14 articles (10/2011 - 10/2003)
10.	Snijder, Eric J: 13 articles (08/2015 - 03/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Severe Acute Respiratory Syndrome:

1.	VaccinesIBA 10/15/2008 - "Effective vaccines should confer long-term protection against future outbreaks of severe acute respiratory syndrome (SARS) caused by a novel zoonotic coronavirus (SARS-CoV) with unknown animal reservoirs. " 05/01/2006 - "This study evaluated the impact of preexisting immunity to human adenovirus on the efficacy of adenovirus-based vaccines against the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). " 08/01/2012 - "Our previous studies have shown that the receptor-binding domain (RBD) in the spike protein of severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) is a key target for the development of SARS vaccines. " 01/01/2014 - "Development of vaccines for preventing a future pandemic of severe acute respiratory syndrome (SARS) caused by SARS coronavirus (SARS-CoV) and for biodefense preparedness is urgently needed. " 04/01/2010 - "Development of vaccines is essential for the prevention of future recurrences of severe acute respiratory syndrome (SARS), caused by the SARS coronavirus (SARS-CoV). "
2.	AntibodiesIBA 10/01/2004 - "To study the response of specific antibodies against severe acute respiratory syndrome (SARS)-CoV in patients infected with SARS. " 12/01/2014 - "Effects of human anti-spike protein receptor binding domain antibodies on severe acute respiratory syndrome coronavirus neutralization escape and fitness." 01/08/2007 - "We investigated whether a recombinant native full-length S-protein trimer (triSpike) of severe acute respiratory syndrome coronavirus (SARS-CoV) was able to elicit a neutralizing and protective immune response in animals and analyzed the capacity of anti-S antibodies to mediate antibody-dependent enhancement (ADE) of virus entry in vitro and enhancement of replication in vivo. " 10/16/2006 - "Neutralizing effects of antibodies targeting the C-terminal stalk (S2) subunit of the spike protein of severe acute respiratory syndrome coronavirus have previously been reported, although its mechanism remained elusive. " 05/15/2006 - "Cross-neutralization of human and palm civet severe acute respiratory syndrome coronaviruses by antibodies targeting the receptor-binding domain of spike protein."
3.	Immunoglobulin G (IgG)IBA 03/01/2005 - "[Study on the dynamics of IgG antibody in 311 patients with severe acute respiratory syndrome]." 07/01/2012 - "Potential cross-reactivity of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) nucleocapsid (N)-based IgG ELISA assay for plasma samples from HIV-1 positive intravenous drug users (IDUs)." 03/01/2007 - "Recombinant severe acute respiratory syndrome (SARS) nucleocapsid and spike protein-based immunoglobulin G immunoassays were developed and evaluated. " 01/01/2007 - "We evaluated the positive rate for severe acute respiratory syndrome (SARS) -CoV IgG antibody among Taiwanese healthcare workers (HCWs). " 06/01/2006 - "We recruited 353 and 361 children, respectively, from the high-risk and low-risk areas and collected 3 to 5 mL of blood for severe acute respiratory syndrome coronavirus IgG antibody testing by immunofluorescence antibody assay and confirmation by neutralization test. "
4.	Ribavirin (Virazole)FDA LinkGeneric 04/01/2007 - "To distinguish adverse events related to ribavirin therapy from those attributable to severe acute respiratory syndrome (SARS), and to determine the rate of potential ribavirin-related adverse events. " 04/01/2007 - "Adverse events associated with high-dose ribavirin: evidence from the Toronto outbreak of severe acute respiratory syndrome." 04/01/2007 - "The treatment of pregnant women with severe acute respiratory syndrome should be without ribavirin." 09/01/2005 - "During the Severe Acute Respiratory Syndrome (SARS) outbreak in Hong Kong in 2003, patients were treated with very high doses of corticosteroid and ribavirin. " 07/01/2005 - "Adverse effects of ribavirin and outcome in severe acute respiratory syndrome: experience in two medical centers."
5.	Neutralizing AntibodiesIBA 02/01/2009 - "Neutralizing antibody against severe acute respiratory syndrome (SARS)-coronavirus spike is highly effective for the protection of mice in the murine SARS model." 12/18/2009 - "To understand the mechanism by which a virus escapes from antibody-mediated neutralization, we have investigated the interactions of non-neutralizing and neutralizing antibodies at an epitope cluster on the spike protein of severe acute respiratory syndrome coronavirus (SARS-CoV). " 04/01/2006 - "Mucosal immunization with surface-displayed severe acute respiratory syndrome coronavirus spike protein on Lactobacillus casei induces neutralizing antibodies in mice." 11/01/2005 - "Using the Taiwan nationwide laboratory-confirmed severe acute respiratory syndrome (SARS) database, we analyzed neutralizing antibody in relation to clinical outcomes. " 10/01/2005 - "A seroepidemiologic study was conducted in North China in 2003 to determine the neutralizing antibody titer of severe acute respiratory syndrome (SARS) convalescent sera. "
6.	OxygenIBA 10/01/2008 - "Survey and evaluation of modified oxygen delivery devices used for suspected severe acute respiratory syndrome and other high-risk patients in Hong Kong." 03/01/2004 - "Dispersal of respiratory droplets with open vs closed oxygen delivery masks: implications for the transmission of severe acute respiratory syndrome." 11/01/2003 - "To evaluate the relationship among chest radiographs, oxygen supplementation requirement, and treatment response in severe acute respiratory syndrome (SARS). " 03/01/2004 - "Nosocomial transmission of droplet-borne respiratory infections such as severe acute respiratory syndrome (SARS) may be influenced by the choice of oxygen face mask. " 05/01/2004 - "Intravenous drip with oxygen-enriched liquids was given to 6 cases suffering from severe acute respiratory syndrome (SARS), and 3 cases of acquired immune deficiency syndrome (AIDS) in the course of treatment for 1 to 5 days, 500-700 ml per day. "
7.	Povidone-Iodine (Betadine)FDA LinkGeneric 01/01/2006 - "The efficacy of several povidone-iodine (PVP-I) products, a number of other chemical agents and various physical conditions were evaluated for their ability to inactivate the severe acute respiratory syndrome coronavirus (SARS-CoV). " 11/01/2004 - "The efficacy of several povidone-iodine (PVP-I) products, a number of other chemical agents, and various physical conditions were evaluated for their ability to inactivate the severe acute respiratory syndrome coronavirus (SARS-CoV). "
8.	AntigensIBA 08/01/2003 - "To study the expression of the immune cell markers and their active antigens in the involved tissues of patients with severe acute respiratory syndrome (SARS). " 12/01/2015 - "Severe Acute Respiratory Syndrome Coronavirus ORF7a Inhibits Bone Marrow Stromal Antigen 2 Virion Tethering through a Novel Mechanism of Glycosylation Interference." 10/01/2011 - "One-hundred and thirty confirmed cases of severe acute respiratory syndrome (SARS) were recruited to evaluate their anti-SARS-coronavirus (CoV) antibody status and human leukocyte antigen (HLA) types in September 2006, 3 y after the SARS outbreaks in Taiwan. " 01/01/2008 - "Here we report the development of a more-sensitive immunoassay for severe acute respiratory syndrome (SARS) based on an enzyme-linked immunosorbent assay using chemiluminescence (CLEIA) to detect the viral nucleocapsid (N) antigen in nasopharyngeal aspirate (NPA) from patients infected with SARS coronavirus (CoV). " 10/01/2007 - "Persistent memory CD4+ and CD8+ T-cell responses in recovered severe acute respiratory syndrome (SARS) patients to SARS coronavirus M antigen."
9.	Nucleocapsid ProteinsIBA 03/01/2005 - "Biochemical and immunological studies of nucleocapsid proteins of severe acute respiratory syndrome and 229E human coronaviruses." 09/01/2015 - "We identified a novel VSR from coronaviruses, a group of medically important mammalian viruses including Severe acute respiratory syndrome coronavirus (SARS-CoV), and showed that the nucleocapsid protein (N protein) of coronaviruses suppresses RNAi triggered by either short hairpin RNAs or small interfering RNAs in mammalian cells. " 10/15/2009 - "Detection of severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein in human serum using a localized surface plasmon coupled fluorescence fiber-optic biosensor." 08/01/2008 - "Taken together, phosphorylation of the severe acute respiratory syndrome-CoV nucleocapsid protein modulates its activity in translation control and also interferes with its oligomerization and aggregation in stress granules." 06/23/2006 - "Crystal structure of the severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein dimerization domain reveals evolutionary linkage between corona- and arteriviridae."
10.	Antiviral Agents (Antivirals)IBA 12/01/2005 - "Ribavarin should be tested in clinical trials in combination with other antiviral agents for severe acute respiratory syndrome." 01/01/2014 - "The recent emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) necessitates adapting methods that have been used to identify antivirals against severe acute respiratory syndrome coronavirus (SARS-CoV) and developing new approaches to more efficiently screen antiviral drugs. " 05/01/2006 - "Severe acute respiratory syndrome (SARS): development of diagnostics and antivirals." 10/01/2005 - "Development of a homogeneous screening assay for automated detection of antiviral agents active against severe acute respiratory syndrome-associated coronavirus." 01/01/2005 - "Serious outbreaks of severe acute respiratory syndrome (SARS), caused by the newly discovered coronavirus SARS-CoV, occurred between late 2002 and early 2003 and there is an urgent need for effective antiviral agents. "

Therapies and Procedures

1.	Critical Care 11/01/2011 - "Epidemics of acute respiratory disease, such as severe acute respiratory syndrome in 2003, and natural disasters, such as Hurricane Katrina in 2005, have prompted planning in hospitals that offer adult critical care to increase their capacity and equipment inventory for responding to a major demand surge. " 05/01/2008 - "Three years following the global outbreak of severe acute respiratory syndrome (SARS), a national, Web-based survey of Canadian nurses was conducted to assess perceptions of preparedness for disasters and access to support mechanisms, particularly for nurses in emergency and critical care units. " 11/01/2007 - "Factors associated with critical-care healthcare workers' adherence to recommended barrier precautions during the Toronto severe acute respiratory syndrome outbreak." 01/01/2005 - "The 2003 global outbreak of severe acute respiratory syndrome (SARS) provided numerous challenges to the delivery of critical care. " 01/01/2005 - "Severe acute respiratory syndrome and critical care medicine: the Toronto experience."
2.	Mechanical Ventilators (Ventilator) 07/01/2012 - "Eight of nine retrospective observational studies found that mask and/or respirator use was independently associated with a reduced risk of severe acute respiratory syndrome (SARS). " 10/01/2011 - "Face masks or respirators are commonly worn by medical professionals and patients for protection against respiratory tract infection and the spread of illnesses, such as severe acute respiratory syndrome and pandemic influenza (H1N1). "
3.	Aftercare (After-Treatment) 09/01/2003 - "To report the initial experience regarding thin-section computed tomographic (CT) findings in patients with severe acute respiratory syndrome (SARS) who improved clinically after treatment. " 01/01/2005 - "To study the function of lymphocytes and the expression pattern of 24 repertoire TCR Vbeta in the convalescent patients with severe acute respiratory syndrome(SARS) after treatment by combination of traditional Chinese and Western medicine. "
4.	Cardiopulmonary Resuscitation (CPR) 07/01/2007 - "The effect of the severe acute respiratory syndrome (SARS) outbreak on the willingness of laypersons to provide bystander cardiopulmonary resuscitation (CPR) using standard CPR (SCPR) or compression-only CPR (CCPR) was evaluated. " 07/01/2007 - "Effect of severe acute respiratory syndrome on bystander willingness to perform cardiopulmonary resuscitation (CPR)--is compression-only preferred to standard CPR?" 01/01/2011 - "Research has investigated the efficacy of intravenous hyperoxygenated solutions (HOS) as auxiliary oxygen supplies in several hypoxic states including cardiopulmonary resuscitation, respiratory failure, cerebrovascular disease, myocardial ischaemia, severe acute respiratory syndrome, poisoning, neonatal hypoxia, altitude sickness, large burns and traumatic haemorrhagic shock. "
5.	Positive-Pressure Respiration (PEEP) 10/01/2003 - "[Evaluation of noninvasive positive pressure ventilation in treatment for patients with severe acute respiratory syndrome]." 05/31/2003 - "To observe the application and the roles of non-invasive positive pressure ventilation (NIPPV) in the treatment of severe acute respiratory syndrome (SARS). " 05/31/2003 - "[Clinical observation of non-invasive positive pressure ventilation (NIPPV) in the treatment of severe acute respiratory syndrome (SARS)]." 10/01/2003 - "To analyze the effects of noninvasive positive pressure ventilation (NIPPV) on oxygenation of severe acute respiratory syndrome (SARS) patients, and to discuss the timing point for mechanical ventilation. " 09/01/2004 - "To describe the blood gas features and short-term outcomes of noninvasive positive pressure ventilation (NPPV) treatment for acute respiratory failure (ARF) in patients with severe acute respiratory syndrome (SARS) in this retrospective case series study sought. "