Abstract | OBJECTIVE: METHODS: Twenty-six patients received a 4-day chronomodulated infusion of L-OHP, 5-Fu and FA. L-OHP (25 mg.m(-2).d(-1)) infused from 10:00 am to 22:00 pm, and followed by 5-Fu (600 mg.m(-2).d(-1)) and FA (300 mg.m(-2).d(-1)) from 22:00 pm to 10:00 am for 4 days using a multichannel programmable pump, every 2 weeks as an cycle for at least 2 cycles. RESULTS: Twenty-six patients with previously untreated advanced gastric cancer were eligible. Two complete and 13 partial remissions were observed with an overall response rate of 57.7%. Stable disease was observed in 6 patients (23.1%) and progressive disease in five (19.2%). Four of these patients underwent surgery. The median remission time was 3.5 months and time to tumor progression ( TTP) was 4.5 months. The median overall survival time was 8 months. A total of 80 cycles were given without any grade 4 toxicity observed, but grade 3 thrombocytopenia (1.3%) and mucositis (1.3%) in one patient, two grade 3 neutropenia (2.5%) and nausea/ vomiting (2.5%) in 2. CONCLUSION:
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Authors | Jian-wei Lu, Zhao-fei Zhou, Bi-jian Yin, De-lin Liu, Ji-feng Feng, Liang-jun Zhu, Liang-xi Pan |
Journal | Zhonghua zhong liu za zhi [Chinese journal of oncology]
(Zhonghua Zhong Liu Za Zhi)
Vol. 27
Issue 11
Pg. 695-7
(Nov 2005)
ISSN: 0253-3766 [Print] China |
PMID | 16438895
(Publication Type: Journal Article)
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Chemical References |
- Organoplatinum Compounds
- Oxaliplatin
- Leucovorin
- Fluorouracil
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Topics |
- Adenocarcinoma
(drug therapy)
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Chronotherapy
- Drug Administration Schedule
- Female
- Fluorouracil
(administration & dosage)
- Humans
- Leucovorin
(administration & dosage)
- Male
- Middle Aged
- Organoplatinum Compounds
(administration & dosage)
- Oxaliplatin
- Stomach Neoplasms
(drug therapy)
- Treatment Outcome
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