Efficacy and safety of iodopovidone pleurodesis through tube thoracostomy.

Abstract

OBJECTIVE:

To evaluate the efficacy and safety of iodopovidone as an agent for pleurodesis through tube thoracostomy in patients with recurrent pleural effusions and pneumothorax.

METHODS:

This was a prospective study in which pleurodesis was performed with a solution of 20 mL 10% iodopovidone and 80 mL normal saline solution infused through a tube thoracostomy and left in the pleural cavity for 4 h.

RESULTS:

A total of 64 patients (34 men) with a mean (+/-SD) age of 47.1 +/- 15.4 years were included. There were 37 cases of pleural effusion and 27 of pneumothorax. A complete response (neither reaccumulation of fluid nor recurrence of pneumothorax) was obtained in 32 (86.5%) patients with pleural effusion and 25 (92.6%) patients with pneumothorax. A second procedure (i.e. repeated pleurodesis) was attempted successfully in four patients in the pleural effusion group. All patients experienced chest pain to a varying degree as recorded on a Visual Analogue Scale (median 50.5, range 10-95). Seven patients developed fever and one immunocompromised patient developed empyema following the procedure. There were no recurrences at a median follow up of 5 months (range 3-15 months) in the pleural effusion group, and 13 months (range 6-24 months) in the pneumothorax group.

CONCLUSIONS:

Iodopovidone can be used as an effective and safe agent for (chemical) pleurodesis (through tube thoracostomy), which is inexpensive and readily available.

• Authors: Ritesh Agarwal, Ashutosh N Aggarwal, Dheeraj Gupta
• Journal: Respirology (Carlton, Vic.) (Respirology) Vol. 11 Issue 1 Pg. 105-8 (Jan 2006) ISSN: 1323-7799 [Print] Australia
• PMID: 16423210 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Anti-Infective Agents, Local
• Sclerosing Solutions
• Povidone-Iodine

Topics

• Anti-Infective Agents, Local (administration & dosage, adverse effects)
• Chest Tubes
• Female
• Humans
• Male
• Middle Aged
• Pleural Effusion (drug therapy)
• Pleurodesis (methods)
• Pneumothorax (therapy)
• Povidone-Iodine (administration & dosage, adverse effects)
• Prospective Studies
• Recurrence
• Safety
• Sclerosing Solutions (administration & dosage, adverse effects)
• Thoracostomy