Abstract | BACKGROUND:
Infection due to methicillin-resistant Staphylococcus aureus (MRSA) is increasingly common in nosocomial and community settings. Daptomycin is a cyclic lipopeptide anti-infective with activity against MRSA, approved for treatment of complicated skin and skin structure infections. Daptomycin may be useful in systemic or local treatment of chronic osteomyelitis. METHODS: RESULTS: Neither tensile nor compressive strength of PMMA was impacted by impregnation with these antimicrobials at a concentration of 7.5% by weight. The peak concentrations of daptomycin and vancomycin in rat tibial bone surrounding a 7.5% daptomycin- and vancomycin-loaded 3 mm PMMA bead were 178 and 49 mg/L, respectively. In the treatment of experimental osteomyelitis, rats assigned to no treatment, daptomycin 50 mg/kg subcutaneously twice daily, daptomycin 60 mg/kg subcutaneously twice daily, and vancomycin 50 mg/kg intraperitoneally twice daily had 6.4, 4.1, 4.0 and 4.5 median log10 cfu/g of bone at the end of 21 days of therapy. All systemic anti-infectives studied were more active than was no treatment. Daptomycin- or vancomycin-loaded PMMA did not, however, exhibit microbiological efficacy alone or adjunctively, as assessed 21 days after implantation. CONCLUSIONS:
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Authors | Mark S Rouse, Kerryl E Piper, Melissa Jacobson, David J Jacofsky, James M Steckelberg, Robin Patel |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 57
Issue 2
Pg. 301-5
(Feb 2006)
ISSN: 0305-7453 [Print] England |
PMID | 16361330
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Excipients
- Vancomycin
- Polymethyl Methacrylate
- Daptomycin
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Topics |
- Animals
- Anti-Bacterial Agents
(administration & dosage, pharmacology, therapeutic use)
- Chemistry, Pharmaceutical
- Chronic Disease
- Daptomycin
(administration & dosage, pharmacology, therapeutic use)
- Excipients
- Hardness Tests
- Male
- Methicillin Resistance
- Microbial Sensitivity Tests
- Osteomyelitis
(drug therapy, pathology)
- Polymethyl Methacrylate
- Rats
- Rats, Wistar
- Staphylococcal Infections
(drug therapy, pathology)
- Staphylococcus aureus
(drug effects)
- Vancomycin
(administration & dosage, pharmacology, therapeutic use)
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