Abstract | OBJECTIVE: METHODS: Standard microcytotoxicity test and polymerase chain reaction-sequence specific primers method were used to detect the HLA class I antigens and HLA-DRB1 and DQB1 alleles in 27 patients with PV and results were compared with control group. RESULTS: Gene and phenotype frequencies of HLA-A3, A26(10), B60(40), and B13 (27.99%, 48%; 16.11%, 30%; 23.02%, 41%; 16.11%, 30%, respectively) increased significantly in PV group compared with control (1.01%, 2%; 0.5%, 1%; 4.61%, 9%; 5.13%, 10%, respectively). After P value correction, the difference of A3, A26 (10), and B60 (40) between the two groups was still significant. The gene frequencies of HLA-DRB1*140x (1401, 1404, 1405, 1407, 1408), DRB1*120x, and DQB1*0503 alleles in PV group (42.26%, 25.46%, and 23.02%) were significantly higher than control group (5.09%, 7.74%, and 1.89%). After P value correction, the difference was still significant between the two groups. CONCLUSION: PV significantly relates with HLA in PV patients of Han nation of northeast China.
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Authors | Long Geng, Yan Wang, Ning Zhai, Ya-Ni Lu, Fang-Ji Song, Hong-Duo Chen |
Journal | Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih
(Chin Med Sci J)
Vol. 20
Issue 3
Pg. 166-70
(Sep 2005)
ISSN: 1001-9294 [Print] China |
PMID | 16261886
(Publication Type: Journal Article)
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Chemical References |
- HLA-A Antigens
- HLA-A3 Antigen
- HLA-B Antigens
- HLA-B60 antigen
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DQB1 antigen
- HLA-DR Antigens
- HLA-DRB1 Chains
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Topics |
- Adult
- Aged
- Asian People
(ethnology)
- China
(ethnology)
- Female
- Gene Frequency
- HLA-A Antigens
(genetics)
- HLA-A3 Antigen
(genetics)
- HLA-B Antigens
(genetics)
- HLA-DQ Antigens
(genetics)
- HLA-DQ beta-Chains
- HLA-DR Antigens
(genetics)
- HLA-DRB1 Chains
- Humans
- Male
- Middle Aged
- Pemphigus
(genetics)
- Phenotype
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