[Expression and significance of CD44v6 and MMP-9 in laryngeal squamous cell carcinoma].

Abstract

OBJECTIVE:

To investigate the clinical implication and the expression of CD44v6 and MMP-9 protein in laryngeal squamous cell carcinoma (LSCC).

METHOD:

Twenty-seven samples of LSCC and eight biopsies of adjacent non-cancerous tissue were detected with immunohistochemical technique (SABC method). The relationship between positive expression of CD44v6 or MMP-9 in LSCC and invasion or metastasis was analyzed.

RESULT:

Both CD44v6 and MMP-9 overexpressed in LSCC. The positive expression of CD44v6 was correlated with LSCC pathologic grade, cervical lymph node metastasis and postoperation survival rate (P < 0.05). The expression of MMP-9 was positively correlated with clinical staging and cervical lymph node metastasis (P < 0.05). There was a significant positive correlation between the expression of CD44v6 and MMP-9 (P < 0.01).

CONCLUSION:

There is a relationship between the expression of CD44 and MMP-9. CD44v6 and MMP-9 might be served as an objective indicator for lymph nodal metastatic potency, tumor invasion and prognosis in LSCC.

• Authors: Gang Qin, Wanrong Li, Xingwang Sun, Lin Zhu, Zhengnong Chen
• Journal: Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology (Lin Chuang Er Bi Yan Hou Ke Za Zhi) Vol. 19 Issue 15 Pg. 688-91 (Aug 2005) China
• PMID: 16248506 (Publication Type: Journal Article)

Chemical References

• CD44v6 antigen
• Hyaluronan Receptors
• Matrix Metalloproteinase 9

Topics

• Adult
• Aged
• Carcinoma, Squamous Cell (metabolism, pathology)
• Female
• Humans
• Hyaluronan Receptors (metabolism)
• Laryngeal Neoplasms (metabolism, pathology)
• Lymphatic Metastasis
• Male
• Matrix Metalloproteinase 9 (metabolism)
• Middle Aged
• Neoplasm Staging
• Prognosis