Chemokines: integrators of pain and inflammation.

Abstract

Chronic (neuropathic) pain is one of the most widespread and intractable of human complaints, as well as being one of the most difficult syndromes to treat successfully with drugs or surgery. The development of new therapeutic approaches to the treatment of painful neuropathies requires a better understanding of the mechanisms that underlie the development of these chronic pain syndromes. It is clear that inflammatory responses often accompany the development of neuropathic pain, and here we discuss the idea that chemokines might be key to integrating the development of pain and inflammation and could furnish new leads in the search for effective analgesic agents for the treatment of painful neuropathies.

• Authors: Fletcher A White, Sonia K Bhangoo, Richard J Miller
• Journal: Nature reviews. Drug discovery (Nat Rev Drug Discov) Vol. 4 Issue 10 Pg. 834-44 (Oct 2005) ISSN: 1474-1776 [Print] England
• PMID: 16224455 (Publication Type: Journal Article, Review)

Chemical References

• Chemokines

Topics

• Chemokines (adverse effects, chemistry, metabolism)
• Humans
• Inflammation (complications, etiology, metabolism)
• Pain (complications, etiology)