Abstract |
Cysteinyl leukotrienes (cysLTs) play important roles in bronchial asthma, and can mediate bronchial smooth muscle constriction and increase mucous secretion, vascular permeability and cellular infiltration. We identified a novel heterozygous single- nucleotide substitution 10G>A (Glu 4 Lys) in the first exon of the leukotriene C4 synthase gene (LTC4S). This substitution was detected in 5 of 141 allergic patients, but not in 110 nonallergic subjects. There was a difference in the Glu 4 Lys frequency between the allergic patients and nonallergic subjects (Fisher's exact test, p=0.0460). The five patients with Glu 4 Lys had allergic diseases such as bronchial asthma and/or allergic dermatitis. Furthermore, a familial analysis of Glu 4 Lys revealed a link with allergic diseases. Thus, our results suggest that Glu 4 Lys in the LTC4S might be associated with allergic diseases.
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Authors | Kaori Yoshikawa, Eiko Matsui, Hideo Kaneko, Toshiyuki Fukao, Ryosuke Inoue, Takahide Teramoto, Shinji Shinoda, Osamu Fukutomi, Minako Aoki, Kimiko Kasahara, Naomi Kondo |
Journal | International journal of molecular medicine
(Int J Mol Med)
Vol. 16
Issue 5
Pg. 827-31
(Nov 2005)
ISSN: 1107-3756 [Print] Greece |
PMID | 16211251
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Glutamic Acid
- Glutathione Transferase
- leukotriene-C4 synthase
- Lysine
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Topics |
- Adolescent
- Adult
- Amino Acid Substitution
(genetics)
- Asthma
(genetics)
- Case-Control Studies
- Child
- Child, Preschool
- Dermatitis, Atopic
(genetics)
- Female
- Glutamic Acid
(genetics)
- Glutathione Transferase
(genetics)
- Humans
- Hypersensitivity, Immediate
(genetics)
- Infant
- Lysine
(genetics)
- Male
- Point Mutation
- Respiratory Hypersensitivity
(genetics)
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