Abstract | BACKGROUND: 1,25-dihydroxy-22-ovavitamin D(3) (22-oxacalcitriol, OCT) was recently introduced commercially as an analogue of 1,25 ( OH)(2) vitamin D(3), but one which has less pronounced calcemic activity. METHODS: RESULTS: In the randomized trial, intact PTH levels were significantly suppressed within 4 weeks after the initiation of each therapy, and this effect was well maintained thereafter in both treatment groups. While intact PTH was significantly lower at 4 weeks in the calcitriol pulse group than in the OCT group (P = 0.02), no statistical differences were observed during later treatment periods. BAP was reduced equally by each treatment. At 4 weeks (P = 0.02) and thereafter (P = 0.06), serum calcium was higher among calcitriol-treated patients than among those who received OCT treatment. Eight of 24 patients who were refractory to oral calcitriol pulse therapy responded to intravenous OCT. The patients who responded tended to have lower serum intact PTH and phosphorus levels and smaller parathyroid glands at the start of OCT treatment than nonresponders. CONCLUSIONS:
|
Authors | Shigeo Tamura, Kazue Ueki, Keiichi Mashimo, Yoshito Tsukada, Miyuki Naitoh, Yukiko Abe, Hironobu Kawai, Akiyasu Tsuchida, Ryoji Wakamatsu, Yoshihisa Nojima |
Journal | Clinical and experimental nephrology
(Clin Exp Nephrol)
Vol. 9
Issue 3
Pg. 238-43
(Sep 2005)
ISSN: 1342-1751 [Print] Japan |
PMID | 16189633
(Publication Type: Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Parathyroid Hormone
- Alkaline Phosphatase
- Calcitriol
- maxacalcitol
- Calcium
|
Topics |
- Administration, Oral
- Aged
- Alkaline Phosphatase
(blood)
- Bone and Bones
(enzymology)
- Calcitriol
(administration & dosage, adverse effects, analogs & derivatives)
- Calcium
(blood)
- Female
- Humans
- Hypercalcemia
(chemically induced)
- Hyperparathyroidism, Secondary
(drug therapy, prevention & control)
- Injections, Intravenous
- Male
- Middle Aged
- Parathyroid Hormone
(blood)
- Pulse Therapy, Drug
- Renal Dialysis
(adverse effects)
|