Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model.

Abstract	The purpose of this study was to examine the involvement of the transient receptor potential vanilloid receptor 1 (TRPV1) in inflammatory processes observed in murine allergic contact dermatitis (ACD). Oxazolone-induced ACD evoked a significant ear swelling after 24-72 h. It was augmented in TRPV1 knockout mice at all time points and supported by histological analysis and measure of TNF-alpha. However, tissue swelling and cytokine generation was significantly reduced in both neurokinin 1 receptor and calcitonin gene-related peptide (CGRP) knockout mice. A protective involvement of the TRPV1 receptor was identified of contact dermatitis distinct from mechanisms involving the major pro-inflammatory neuropeptides.
Authors	Agnes Bánvölgyi, László Pálinkás, Tímea Berki, Natalie Clark, Andrew D Grant, Zsuzsanna Helyes, Gábor Pozsgai, János Szolcsányi, Susan D Brain, Erika Pintér
Journal	Journal of neuroimmunology (J Neuroimmunol) Vol. 169 Issue 1-2 Pg. 86-96 (Dec 2005) ISSN: 0165-5728 [Print] Netherlands
PMID	16188326 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Adjuvants, Immunologic Cytokines Diterpenes Piperidines Quinuclidines TRPV Cation Channels TRPV1 receptor SR 140333 Oxazolone resiniferatoxin Calcitonin Gene-Related Peptide
Topics	Adjuvants, Immunologic (toxicity) Animals Calcitonin Gene-Related Peptide (deficiency, physiology) Cytokines (metabolism) Dermatitis, Allergic Contact (etiology, metabolism, prevention & control) Disease Models, Animal Diterpenes (administration & dosage) Ear Diseases (drug therapy, etiology, pathology) Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Neutrophils (metabolism) Oxazolone (toxicity) Piperidines (administration & dosage) Quinuclidines (administration & dosage) TRPV Cation Channels (agonists, antagonists & inhibitors, deficiency, physiology) Time Factors

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