Highly cytotoxic iron(II) complexes with pentadentate pyridyl ligands as a new class of anti-tumor agents.

Abstract

The iron(II) complexes and with pentadentate pyridyl ligands are stable under physiological conditions and exhibit higher cytotoxicities toward a series of human carcinoma cell lines than cisplatin; can significantly increase intracellular oxidant levels, cleave supercoiled plasmid DNA in vitro without addition of a reductant and induce apoptotic cell death in human cervical epithelioid carcinoma cells (HeLa) as observed in flow cytometric studies.

• Authors: Ella Lai-Ming Wong, Guo-Su Fang, Chi-Ming Che, Nianyong Zhu
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Issue 36 Pg. 4578-80 (Sep 28 2005) ISSN: 1359-7345 [Print] England
• PMID: 16158120 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• DNA, Superhelical
• Ferrous Compounds
• Iron Compounds
• Oxidants
• Pyridines
• Reactive Oxygen Species
• Cisplatin

Topics

• Antineoplastic Agents (chemical synthesis, pharmacology)
• Apoptosis (drug effects)
• Cell Line, Tumor
• Chemical Phenomena
• Chemistry, Physical
• Cisplatin (pharmacology)
• DNA, Superhelical (drug effects)
• Drug Screening Assays, Antitumor
• Ferrous Compounds (chemical synthesis, pharmacology)
• Flow Cytometry
• HeLa Cells
• Humans
• Iron Compounds (chemical synthesis, pharmacology)
• Oxidants (metabolism)
• Pyridines (chemical synthesis, pharmacology)
• Reactive Oxygen Species (metabolism)