Effect of combined therapy of danaparoid sodium and tranexamic acid on chronic disseminated intravascular coagulation associated with abdominal aortic aneurysm.

Abstract

Chronic disseminated intravascular coagulation (DIC) is a well-known complication of aortic aneurysm. A 63-year-old man with bleeding tendency and a large palpable abdominal aortic aneurysm (AAA) was diagnosed as having fibrinolysis dominant DIC by the excessive activation of both coagulation and fibrinolysis (plasmin -alpha2 plasmin inhibitor complex concentration is usually >4 microg/ml). Although several treatments were tried, DIC could not be controlled until the patient was given combined therapy of danaparoid (1,250 U/12 h, bolus IV) and tranexamic acid (0.5 g x 3/day, oral administration). This therapy may be beneficial when control for bleeding is required without restricting the ambulatory movement of patients by continuous drip.

• Authors: Yasuo Ontachi, Hidesaku Asakura, Masahisa Arahata, Yasuko Kadohira, Mio Maekawa, Tomoe Hayashi, Masahide Yamazaki, Eriko Morishita, Masanori Saito, Shinji Minami, Shinji Nakao
• Journal: Circulation journal : official journal of the Japanese Circulation Society (Circ J) Vol. 69 Issue 9 Pg. 1150-3 (Sep 2005) ISSN: 1346-9843 [Print] Japan
• PMID: 16127203 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anticoagulants
• Antifibrinolytic Agents
• Dermatan Sulfate
• Tranexamic Acid
• Chondroitin Sulfates
• Heparitin Sulfate
• danaparoid

Topics

• Anticoagulants (administration & dosage)
• Antifibrinolytic Agents (administration & dosage)
• Aortic Aneurysm, Abdominal (complications, diagnostic imaging, drug therapy)
• Chondroitin Sulfates (administration & dosage)
• Dermatan Sulfate (administration & dosage)
• Disseminated Intravascular Coagulation (diagnostic imaging, drug therapy, etiology)
• Drug Therapy, Combination
• Heparitin Sulfate (administration & dosage)
• Humans
• Male
• Middle Aged
• Radiography
• Tranexamic Acid (administration & dosage)