Abstract | AIM: METHODS: Twelve-week-old female IL-1-receptor type 1-homozygous-knockout mice (IL-1R1(-/-)) and their wild-type littermates (WT) were orally inoculated with H pylori (Hp group), while other cohorts received oral inoculation of culture medium (Cont group). Thirteen weeks after the inoculation, the mice were examined. The plasma and stomach ghrelin levels and the gastric preproghrelin mRNA were measured. RESULTS: Although the WT mice with H pylori infection showed a significantly decreased body weight as compared with that of the animals without H pylori infection, H pylori infection did not influence the body weight of the IL-1R1-knockout (IL-1R1(-/-)) mice. In the H pylori-infected IL-1R1(-/-) mice, the total and active ghrelin levels in the plasma were significantly increased, and the gastric ghrelin level was decreased. No significant differences were noted in the gastric preproghrelin mRNA expression. CONCLUSION:
|
Authors | Yuka Abiko, Hidekazu Suzuki, Tatsuhiro Masaoka, Sachiko Nomura, Kumiko Kurabayashi, Hiroshi Hosoda, Kenji Kangawa, Toshifumi Hibi |
Journal | World journal of gastroenterology
(World J Gastroenterol)
Vol. 11
Issue 27
Pg. 4148-53
(Jul 21 2005)
ISSN: 1007-9327 [Print] United States |
PMID | 16015681
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Ghrelin
- Interleukin-1
- Peptide Hormones
- Receptors, Interleukin-1
- Receptors, Interleukin-1 Type I
|
Topics |
- Animals
- Body Weight
(physiology)
- Female
- Ghrelin
- Helicobacter Infections
(blood, physiopathology)
- Helicobacter pylori
- Homozygote
- Interleukin-1
(metabolism)
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Peptide Hormones
(blood)
- Receptors, Interleukin-1
(genetics, metabolism)
- Receptors, Interleukin-1 Type I
|