[Efficacy of conventional mono mac therapy and mono mac chronotherapy of painless myocardial ischemia in patients with insulin-independent diabetes].

Abstract

60 patients, suffering from coronary heart disease with painless myocardial ischemia (PMI) and insulin-independent diabetes (IID), were randomized into two groups. The first group included 18 patients, who received conventional mono mac therapy in a dose of 20 mg twice a day, the second--42 patients, whose treatment consisted in mono mac chronotherapy, i.e. they were administered a single dose of 10 to 20 mg of the drug 30 minutes before a PMI episode, revealed by means of Holter ECG-monitoring, before the beginning of the treatment. All the patients underwent examination, which consisted in Holter ECG-monitoring and Echo-CG, before and after a 15-day mono mac therapy course and adequate IID treatment. The study demonstrated that the total length and number of PMI episodes within a 24-hour interval, as well as the average episode length, were significantly less in the second group, compared with conventionally treated patients. The chronotherapy allowed a 2-fold reduction in mono mac doses.

• Authors: R M Zaslavskaia, B A Aĭtmagambetova
• Journal: Klinicheskaia meditsina (Klin Med (Mosk)) Vol. 83 Issue 5 Pg. 52-4 ( 2005) ISSN: 0023-2149 [Print] Russia (Federation)
• PMID: 15984585 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Vasodilator Agents
• Isosorbide Dinitrate
• isosorbide-5-mononitrate

Topics

• Aged
• Chronotherapy (methods)
• Diabetes Mellitus, Type 2 (complications)
• Electrocardiography, Ambulatory (drug effects)
• Female
• Follow-Up Studies
• Humans
• Isosorbide Dinitrate (administration & dosage, analogs & derivatives)
• Male
• Middle Aged
• Myocardial Ischemia (complications, drug therapy)
• Treatment Outcome
• Vasodilator Agents (administration & dosage)