Abstract | BACKGROUND: METHODS: PC-3MM2 human PCa cells were injected into the prostate of nude mice. Three days later, the mice were randomized into four groups: saline control, paclitaxel, AEE788, and AEE788 and paclitaxel. The mice were treated for 5 weeks and necropsied. Tumor incidence, weight, and incidence of lymph node metastasis were recorded. Tumor tissue was analyzed immunohistochemically. RESULTS: CONCLUSION: Blockade of EGF-R and VEGF-R signaling pathways coupled with chemotherapy suppressed the progressive growth and metastasis of human PCa cells growing orthotopically in nude mice.
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Authors | S Yazici, S J Kim, J E Busby, J He, P Thaker, K Yokoi, D Fan, I J Fidler |
Journal | The Prostate
(Prostate)
Vol. 65
Issue 3
Pg. 203-15
(Nov 01 2005)
ISSN: 0270-4137 [Print] United States |
PMID | 15948138
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, P.H.S.)
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Copyright | Copyright 2005 Wiley-Liss, Inc |
Chemical References |
- Antineoplastic Agents, Phytogenic
- Platelet Endothelial Cell Adhesion Molecule-1
- Protein Kinase Inhibitors
- Purines
- ErbB Receptors
- Receptors, Vascular Endothelial Growth Factor
- AEE 788
- Paclitaxel
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Topics |
- Animals
- Antineoplastic Agents, Phytogenic
(pharmacology)
- Apoptosis
(drug effects)
- Capillary Permeability
(drug effects)
- Cell Growth Processes
(drug effects)
- Cell Line, Tumor
- ErbB Receptors
(antagonists & inhibitors, metabolism)
- Humans
- In Situ Nick-End Labeling
- Male
- Mice
- Mice, Nude
- Microscopy, Fluorescence
- Neovascularization, Pathologic
(drug therapy)
- Paclitaxel
(pharmacology)
- Phosphorylation
- Platelet Endothelial Cell Adhesion Molecule-1
(metabolism)
- Prostatic Neoplasms
(blood supply, drug therapy, enzymology, pathology)
- Protein Kinase Inhibitors
(pharmacology)
- Purines
(pharmacology)
- Receptors, Vascular Endothelial Growth Factor
(antagonists & inhibitors, metabolism)
- Xenograft Model Antitumor Assays
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