Is granulocyte colony-stimulating factor level predictive for human IVF outcome?

Abstract

BACKGROUND:

We investigated granulocyte colony-stimulating factor (G-CSF) in human reproduction.

METHODS:

From a total sample of 93 patients, we analysed in group 1 (n = 82) the level of G-CSF and estradiol (E(2)) in serum and follicular fluid (FF) on day of follicular puncture (FP). Furthermore, in response to ovarian stimulation, G-CSF levels in serum were compared between low (n = 11), moderate (n = 53) and high (n = 18) response patients. In group 2 (n = 23) serum for G-CSF assessment was collected throughout menstrual cycle until gestation. Group 3 (n = 11) patients with endometriosis were assessed for G-CSF in serum and FF on day of FP without further differentiation.

RESULTS:

G-CSF in FF was higher than in serum (P < 0.01). G-CSF in serum increased from low through moderate to high response (P < 0.001); pregnancy rates were 0, 24.5 and 33.5% respectively. G-CSF in serum increased throughout stimulation, reached a peak with ovulation induction (P = 0.01) and decreased until embryo transfer (P=0.001). G-CSF level only in pregnant patients (n = 11) increased from embryo transfer to implantation to gestation (P = 0.005). In endometriosis patients G-CSF in serum and FF was lower than in non-endometriosis patients (P < or = 0.03) and corresponded with low response patients.

CONCLUSIONS:

G-CSF is involved in follicle development and may be a predictor of IVF outcome.

• Authors: A Salmassi, A G Schmutzler, S Schaefer, K Koch, J Hedderich, W Jonat, L Mettler
• Journal: Human reproduction (Oxford, England) (Hum Reprod) Vol. 20 Issue 9 Pg. 2434-40 (Sep 2005) ISSN: 0268-1161 [Print] England
• PMID: 15890733 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Recombinant Proteins
• Granulocyte Colony-Stimulating Factor
• Follicle Stimulating Hormone

Topics

• Adult
• Biomarkers (blood, metabolism)
• Endometriosis (blood)
• Female
• Fertilization in Vitro
• Follicle Stimulating Hormone (therapeutic use)
• Follicular Fluid (metabolism)
• Granulocyte Colony-Stimulating Factor (blood, metabolism)
• Humans
• Infertility, Female (blood, therapy)
• Menstrual Cycle (blood)
• Oocytes
• Ovarian Follicle (metabolism)
• Ovulation (metabolism)
• Ovulation Induction
• Predictive Value of Tests
• Pregnancy
• Pregnancy Outcome
• Recombinant Proteins (therapeutic use)