Expression of p8 protein in breast carcinoma; an inverse relationship with apoptosis.

Abstract

BACKGROUND:

P8 is a transcription factor and its expression is elevated in response to apoptotic stimuli. However, p8 in human carcinoma tissue has not been investigated in depth. In this study, we investigated p8 expression in breast carcinoma.

MATERIALS AND METHODS:

We immunohistochemically investigated p8 expression in 50 cases of breast carcinoma, including 7 non-invasive ductal carcinomas.

RESULTS:

High expression of p8 was observed in 60% of cases, which was inversely related to tumor size and UICC stage. All non-invasive ductal carcinomas diffusely expressed p8. Furthermore, in tumors of 2 cm or larger, the p8 expression was inversely linked to the apoptotic index.

CONCLUSION:

These results suggest that p8 plays a role in the early phase of breast carcinoma progression and especially in tumors of larger size, acting as an inhibitor of apoptosis of breast carcinoma cells.

• Authors: Yasuhiro Ito, Hiroshi Yoshida, Yoshiharu Motoo, Juan Lucio Iovanna, Yasushi Nakamura, Kennichi Kakudo, Takashi Uruno, Yuuki Takamura, Akihiro Miya, Shinzaburo Noguchi, Kanji Kuma, Akira Miyauchi
• Journal: Anticancer research (Anticancer Res) 2005 Mar-Apr Vol. 25 Issue 2A Pg. 833-7 ISSN: 0250-7005 [Print] Greece
• PMID: 15868916 (Publication Type: Journal Article)

Chemical References

• Basic Helix-Loop-Helix Transcription Factors
• DNA-Binding Proteins
• NUPR1 protein, human
• Neoplasm Proteins

Topics

• Apoptosis (physiology)
• Basic Helix-Loop-Helix Transcription Factors
• Breast Neoplasms (metabolism, pathology)
• Carcinoma, Ductal (metabolism, pathology)
• Carcinoma, Lobular (metabolism, pathology)
• DNA-Binding Proteins (biosynthesis)
• Female
• Humans
• Immunohistochemistry
• Middle Aged
• Neoplasm Proteins (biosynthesis)