Prelabour rupture of the membranes at term and unfavourable cervix; a randomized placebo-controlled trial on early intervention with intravaginal prostaglandin E2 gel.

Abstract

Fifty nine women with prelabour rupture of membranes, unfavourable cervix and no evidence of infection or fetal distress were randomized formally to receive prostaglandin E2 (3mg) gel or sterile K-Y Jelly intravaginally. Conservative expectant management was followed for the next 24 hours. The subsequent management of the labour followed departmental protocol. The women who received prostaglandin went into labour sooner and were delivered earlier but the duration of labour was not significantly different. There were no significant differences in other clinical outcomes. There was 1 case of uterine rupture in the prostaglandin group. We conclude that early intervention with prostaglandin E2 gel intravaginally confers no advantage compared with conservative management except for earlier confinement in this group of patients.

• Authors: T Chung, M S Rogers, H Gordon, A Chang
• Journal: The Australian & New Zealand journal of obstetrics & gynaecology (Aust N Z J Obstet Gynaecol) Vol. 32 Issue 1 Pg. 25-7 (Feb 1992) ISSN: 0004-8666 [Print] Australia
• PMID: 1586330 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Gels
• Placebos
• Dinoprostone

Topics

• Administration, Intravaginal
• Adult
• Dinoprostone (administration & dosage)
• Female
• Fetal Membranes, Premature Rupture (therapy)
• Gels
• Humans
• Infant, Newborn
• Labor, Induced
• Placebos
• Pregnancy
• Pregnancy Outcome
• Treatment Outcome