Abstract | BACKGROUND: METHODS AND RESULTS: The population of 9079 patients was divided as follows: thin (body mass index [BMI] <20 kg/m2, 2%), normal weight (BMI 20 to 24.9, 24%), overweight (BMI 25 to 29.9, 45%), and obese (class I: BMI 30 to 34.9, 21%; class II: BMI 35 to 39.9, 6%; class III: BMI > or =40, 2%). Incident diabetes increased progressively with BMI and was somewhat higher in the atenolol arm. Differences in gender and race were detected among the body build groups. Rates (Cox proportional hazard analysis) of the primary composite end point did not differ among body build groups after adjustment for age, gender, race, smoking habit, prevalent cardiovascular disease, and left ventricular hypertrophy. Cardiovascular death was more frequent among thin (P<0.05) and pooled class II-III obesity (both P<0.04) than normal-weight groups. Risk was not attenuated significantly by losartan treatment, nor did it interfere with the greater benefit of losartan- as opposed to atenolol-based treatment. CONCLUSIONS: In the LIFE study, stratification for classes of body build identified increased risk of cardiovascular mortality in both thin and moderately-to-severely obese individuals. This risk was not attenuated significantly by losartan treatment, nor did it interfere with the greater benefit of losartan-based treatment as opposed to atenolol-based treatment.
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Authors | Giovanni de Simone, Kristian Wachtell, Vittorio Palmieri, Darcy A Hille, Gareth Beevers, Björn Dahlöf, Ulf de Faire, Frej Fyhrquist, Hans Ibsen, Stevo Julius, Sverre E Kjeldsen, Ole Lederballe-Pedersen, Lars H Lindholm, Markku S Nieminen, Per Omvik, Suzanne Oparil, Richard B Devereux |
Journal | Circulation
(Circulation)
Vol. 111
Issue 15
Pg. 1924-31
(Apr 19 2005)
ISSN: 1524-4539 [Electronic] United States |
PMID | 15837945
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Aged
- Atenolol
(therapeutic use)
- Body Mass Index
- Body Weight
- Cardiovascular Diseases
(drug therapy, etiology, physiopathology)
- Female
- Humans
- Hypertension
(drug therapy, physiopathology)
- Hypertrophy, Left Ventricular
(drug therapy, physiopathology)
- Losartan
(therapeutic use)
- Male
- Middle Aged
- Obesity
- Proportional Hazards Models
- Risk Assessment
- Somatotypes
(physiology)
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