Nasal exposure to Staphylococcal enterotoxin enhances the development of allergic rhinitis in mice.

Abstract

BACKGROUND:

Staphylococcal enterotoxins (SEs) appear to play a role in the pathogenesis of allergic disease. However, little is known whether the nasal exposure to SE affects the development of allergic rhinitis (AR).

OBJECTIVE:

We sought to determine the in vivo effect of nasal exposure to SE on the development of AR using mouse model.

METHODS:

BALB/c mice were intranasally sensitized with Schistosoma mansoni egg antigen (SmEA) in the presence or absence of staphylococcal enterotoxin B (SEB). Control mice were intranasally sensitized with either SEB or SmEA alone. The production of antigen-specific antibodies including IgE, nasal eosinoplilia and cytokines by nasal mononuclear cells was compared among mice that had or had not received SEB treatment.

RESULTS:

Nasal exposure to SEB enhanced the development of AR in SmEA-sensitized mice, as manifested by SmEA-specific IgE production, nasal eosinophilia, and IL-4 and IL-5 production by nasal mononuclear cells after Ag challenge. This treatment also elicited IFN-gamma production by SmEA-primed cells. In addition, these mice produced SEB-specific IgE whereas mice treated with SEB without SmEA sensitization did not produce SEB-specific IgE or demonstrate nasal eosinophilia.

CONCLUSION:

These results suggest that the nasal exposure to SEB enhances susceptibility to AR although the exposure to SE solely does not induce AR.

• Authors: M Okano, H Hattori, T Yoshino, Y Sugata, M Yamamoto, T Fujiwara, A A Satoskar, A R Satoskar, K Nishizaki
• Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (Clin Exp Allergy) Vol. 35 Issue 4 Pg. 506-14 (Apr 2005) ISSN: 0954-7894 [Print] England
• PMID: 15836761 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Allergens
• Enterotoxins
• Interleukin-5
• Interleukin-4
• Immunoglobulin E
• Interferon-gamma

Topics

• Allergens (immunology)
• Animals
• Antibody Specificity (immunology)
• Cells, Cultured
• Dose-Response Relationship, Immunologic
• Enterotoxins (immunology)
• Eosinophilia (immunology)
• Female
• Immunization
• Immunoglobulin E (immunology)
• Interferon-gamma (immunology)
• Interleukin-4 (immunology)
• Interleukin-5 (immunology)
• Mice
• Mice, Inbred BALB C
• Nose
• Respiratory Hypersensitivity (immunology)
• Rhinitis (immunology)
• Staphylococcus aureus (immunology)