The cause of
sciatica and
low back pain associating with lumbar
disc herniation has not been clearly identified until now.
Inflammation has been shown to occur via immunohistochemical and biochemical methods in
herniated disc tissues. The important prognostic role of
E-selectin has recently been substantiated by other studies in early
rheumatoid arthritis (RA) and
juvenile rheumatoid arthritis (JRA). The important role of adhesion molecules in the initiation and progression of the inflammatory response is well known for
infectious diseases and autoimmune disorders. In our study, we aimed to show the role of
E-selectin as an inflammatory marker and the correlation of
inflammation with straight-leg raise (SLR) test findings and subtype of
disc herniation. We found that the cases with positive SLR test had higher rates of immunostaining with
E-selectin. This led us to think that
E-selectin might play an important role in the activity status of the disease, meaning patients with more limited movement capacity might benefit from
E-selectin antagonist
therapy. Among the many studies performed to identify the relationship between the
inflammation markers and activity of lumbar
disc herniation, this is the first investigation held with
E-selectin.