Abstract | BACKGROUND/AIMS: METHODOLOGY: RESULTS: The amounts of Zn and Fe in non-tumorous liver parenchyma were reduced by liver fibrosis, and the amounts were lower in HCC tissue compared to non-tumorous liver parenchyma. The amounts of Zn and Cu were higher in HCC than the amounts found in CCC and Meta. The amount of Zn in HCC tissue decreased, but the amount of Fe increased in tumors more than 4cm in diameter. CONCLUSIONS: These results suggest that the decrease in the amount of Zn and Fe found in non-tumorous liver parenchyma correlates with liver fibrosis leading to cirrhosis and hepatocarcinogenesis. Also that decreases in Zn and increases of Fe in HCC tissue correlates with HCC tumor progression.
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Authors | Takashi Maeda, Mitsuo Shimada, Norifumi Harimoto, Eiji Tsujita, Shin-ichiro Maehara, Tatsuya Rikimaru, Shiniji Tanaka, Ken Shirabe, Yoshihiko Maehara |
Journal | Hepato-gastroenterology
(Hepatogastroenterology)
2005 Jan-Feb
Vol. 52
Issue 61
Pg. 187-90
ISSN: 0172-6390 [Print] Greece |
PMID | 15783026
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Carcinoma, Hepatocellular
(etiology, metabolism, pathology)
- Case-Control Studies
- Cholangiocarcinoma
(etiology, metabolism, pathology)
- Humans
- Liver
(metabolism, pathology)
- Liver Cirrhosis
(etiology, metabolism, pathology)
- Liver Neoplasms
(etiology, metabolism, pathology)
- Trace Elements
(metabolism)
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