Abstract | INTRODUCTION: CASE REPORT: We report the case of an asymptomatic patient diagnosed after the incidental discovery of bilateral nodular opacities on their chest x-ray. Physical examination and bronchoscopy were normal. The diagnosis of Lymphomatoid Granulomatosis was made on the basis of surgical lung biopsy. Immunohistochemical studies confirmed the B phenotype of the lymphoma with the identification of atypical large CD 20 positive cells. In situ hybridisation confirmed the presence of EBV. In this case the course of the disease was slow. Treatment with anti CD 20 monoclonal antibodies ( rituximab) led initially to a reduction in parenchymal abnormalities and mediastinal adenopathy. CONCLUSION:
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Authors | C Moudir-Thomas, A Foulet-Roge, M Plat, R Kaswin, P Lepic, P Solal-Celigny, F X Lebas |
Journal | Revue des maladies respiratoires
(Rev Mal Respir)
Vol. 21
Issue 6 Pt 1
Pg. 1157-61
(Dec 2004)
ISSN: 0761-8425 [Print] France |
Vernacular Title | Efficacité du Rituximab au cours d'une granulomatose lymphomatoïde. |
PMID | 15767962
(Publication Type: Case Reports, English Abstract, Journal Article)
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Chemical References |
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Murine-Derived
- Antineoplastic Agents
- Rituximab
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Topics |
- Antibodies, Monoclonal
(therapeutic use)
- Antibodies, Monoclonal, Murine-Derived
- Antineoplastic Agents
(therapeutic use)
- Humans
- Lung Diseases
(drug therapy)
- Lymphomatoid Granulomatosis
(drug therapy)
- Male
- Middle Aged
- Rituximab
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