Y-700, a novel inhibitor of xanthine oxidase, suppresses the development of colon aberrant crypt foci and cell proliferation in 1,2-dimethylhydrazine-treated mice.

Abstract

Y-700, 1-[3-cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylic acid, is a newly synthesized inhibitor of xanthine oxidase. This study found that feeding of Y-700 suppressed the development of colonic aberrant crypt foci, precursor lesions of colon cancer, and cell proliferation in 1,2-dimethylhydrazine-treated mice, accompanied by reduced serum urate. These results suggest that Y-700 is a useful agent for the prevention of colon tumorigenesis and that xanthine oxidase plays an important role in the development of colon cancer.

• Authors: Takao Hashimoto, Atsushi Fukunari, Ichimaro Yamada, Noriyuki Yanaka, Dong Chen, Norihisa Kato
• Journal: Bioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem) Vol. 69 Issue 1 Pg. 209-11 (Jan 2005) ISSN: 0916-8451 [Print] England
• PMID: 15665488 (Publication Type: Journal Article)

Chemical References

• 1-(3-cyano-4-neopentyloxyphenyl)pyrazole-4-carboxylic acid
• Pyrazoles
• Xanthine Oxidase
• 1,2-Dimethylhydrazine

Topics

• 1,2-Dimethylhydrazine
• Animals
• Cell Proliferation (drug effects)
• Colon (pathology)
• Colonic Diseases (chemically induced, pathology, prevention & control)
• Dose-Response Relationship, Drug
• Male
• Mice
• Mice, Inbred Strains
• Pyrazoles (pharmacology)
• Xanthine Oxidase (antagonists & inhibitors)