Abstract | OBJECTIVE: METHODS: A population-based study comparing all singleton pregnancies in women with and without two or more consecutive recurrent abortions was conducted. Deliveries occurred during the years 1988-2002. Stratified analysis, using a multiple logistic regression model was performed to control for confounders. RESULTS: During the study period 154,294 singleton deliveries occurred, with 4.9% in patients with history of recurrent consecutive abortions. Using a multivariate analysis, with backward elimination, the following complications were significantly associated with recurrent abortions-advanced maternal age, cervical incompetence, previous CS, diabetes mellitus, hypertensive disorders, placenta previa and abruptio placenta, mal-presentations and PROM. A higher rate of CS was found among patients with previous spontaneous consecutive recurrent abortions (15.9% versus 10.9%; OR = 1.6; 95% CI, 1.5-1.7; P < 0.001). Another multivariate analysis was performed, with CS as the outcome variable, controlling for confounders such as placenta previa, abruptio placenta, diabetes mellitus, hypertensive disorders, previous CS, mal-presentations, fertility treatments and PROM. A history of recurrent abortion was found as an independent risk factor for CS (OR = 1.2; 95% CI, 1.1-1.3; P < 0.001). About 58 cases of inherited thrombophilia were found between the years 2000-2002. These cases were significantly more common in the recurrent abortion as compared to the comparison group (1.2% versus 0.1%; OR = 11.1; 95% CI, 6.5-18.9; P < 0.001). CONCLUSION:
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Authors | Eyal Sheiner, Amalia Levy, Miriam Katz, Moshe Mazor |
Journal | European journal of obstetrics, gynecology, and reproductive biology
(Eur J Obstet Gynecol Reprod Biol)
Vol. 118
Issue 1
Pg. 61-5
(Jan 10 2005)
ISSN: 0301-2115 [Print] Ireland |
PMID | 15596274
(Publication Type: Journal Article)
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Topics |
- Abortion, Habitual
- Abruptio Placentae
(complications, epidemiology)
- Analysis of Variance
- Cesarean Section
(statistics & numerical data)
- Female
- Fetal Growth Retardation
(complications, epidemiology)
- Fetal Membranes, Premature Rupture
(complications)
- Humans
- Hypertension, Pregnancy-Induced
(epidemiology)
- Logistic Models
- Maternal Age
- Placenta Previa
(complications)
- Pregnancy
- Pregnancy Complications
(epidemiology)
- Pregnancy Outcome
- Pregnancy in Diabetics
(complications)
- Uterine Cervical Incompetence
(complications)
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