Placenta Previa

Abnormal placentation in which the PLACENTA implants in the lower segment of the UTERUS (the zone of dilation) and may cover part or all of the opening of the CERVIX. It is often associated with serious antepartum bleeding and PREMATURE LABOR.

Also Known As:

Networked: 760 relevant articles (7 outcomes, 62 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hemorrhage
2.	Polyhydramnios
3.	Moyamoya Disease (Moya-Moya Disease)
4.	Placenta Accreta
5.	Abruptio Placentae (Placental Abruption)

Experts

1.	Matsubara, Shigeki: 17 articles (02/2015 - 01/2003)
2.	Mazor, Moshe: 6 articles (08/2015 - 08/2003)
3.	Usui, Rie: 6 articles (02/2015 - 01/2003)
4.	Ohkuchi, Akihide: 6 articles (02/2015 - 01/2003)
5.	Kuwata, Tomoyuki: 6 articles (02/2015 - 04/2009)
6.	Suzuki, Mitsuaki: 5 articles (06/2014 - 01/2003)
7.	Sheiner, Eyal: 5 articles (07/2011 - 08/2003)
8.	Miura, Kiyonori: 4 articles (12/2015 - 05/2005)
9.	Masuzaki, Hideaki: 4 articles (12/2015 - 05/2005)
10.	Matsubara, S: 4 articles (10/2015 - 01/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Placenta Previa:

1.	alpha-Fetoproteins (AFP)IBA 07/01/2004 - "To evaluate the relationship between maternal serum alpha-fetoprotein (MSAFP) and the risk of persistent placenta previa. " 07/01/2004 - "Association of maternal serum alpha-fetoprotein with persistent placenta previa." 01/01/2001 - "To determine whether increased maternal serum alpha-fetoprotein (MSAFP) level at 15-20 weeks' gestation is a marker of adverse outcomes in women with placenta previa at delivery. " 01/01/2001 - "Association between maternal serum alpha-fetoprotein and adverse outcomes in pregnancies with placenta previa." 02/01/2000 - "Geometric means of maternal serum AFP and hCG concentrations in pregnancies with placenta previa were 1.13 and 0. "
2.	SmokeIBA 04/01/1996 - "The increased risk of both placenta previa and abruptio placentae among women who continue to smoke during pregnancy, is in general, less well recognized, but supported by numerous studies. " 12/01/2014 - "The findings of a higher risk of placenta praevia in patients with endometriosis and in those that smoke are in agreement with the current literature on natural conception. " 05/01/2006 - "Tobacco smoke toxins damage the placenta and may lead to placental abruption, abortion or placenta praevia. " 04/01/1996 - "The purpose of this article is to review the published literature dealing with the risk of placenta previa and abruptio placentae in women who smoke during their pregnancy." 06/01/1980 - "The mothers who stopped smoking had only about half as many fetal and neonatal deaths due to abruptio placentae and one third fewer losses to placenta previa than did nothers who continued to smoke. "
3.	Messenger RNA (mRNA)IBA 02/01/2014 - "In conclusion, expression of hPL mRNA is increased in plasma of women with placenta previa and invasive placenta at 28 to 32 weeks of gestation. " 02/01/2014 - "Median (range) hPL mRNA was significantly higher in women with placenta previa, 782 (10-2301) copies/mL of plasma, and in those with invasive placenta, 615 (522-2102) copies/mL of plasma, when compared to normal pregnancies, 90 (4-4407) copies/mL of plasma, P < .01 and P < .05, respectively. " 05/01/2005 - "Placental mRNA in maternal plasma and its clinical application to the evaluation of placental status in a pregnant woman with placenta previa-percreta." 09/01/2008 - "The purpose of this study was to investigate whether cell-free placental mRNA levels have the potential to predict a placenta previa resulting in hysterectomy. " 09/01/2014 - "In the placenta previa/accreta group, the concentration of cell-free β-HCG mRNA was significantly higher among women who underwent CDs with hysterectomy (4.41, 3.49-7.19) than among women whose CDs did not result in hysterectomy (3.20, 2.78-3.70) (Mann-Whitney U test, P = 0.012). "
4.	Ritodrine (Yutopar)FDA Link 02/01/2004 - "To study the effect of ritodrine therapy on maternal and perinatal outcome in cases of symptomatic placenta previa being managed conservatively. " 06/01/2011 - "At 23 gestational weeks, she was diagnosed as having placenta previa and prophylactic oral ritodrine hydrochloride (15 mg/day) was initiated. " 06/01/2011 - "We report a case of oral-ritodrine-hydrochloride-induced rhabdomyolysis in a pregnant woman with placenta previa without neuromuscular disorders. " 02/01/2004 - "The present prospective study suggests that ritodrine hydrochloride in patients with symptomatic placenta previa tends to prolong the pregnancy and result in an increase in birth weight of the babies without causing any adverse effect on the mother and fetus." 12/01/2002 - "A 31-year-old woman was treated with infusion of ritodrine chloride for preterm labor and placenta previa. "
5.	Cocaine (Cocaine HCl)IBA 03/01/1994 - "This study examined the relationship between two maternal exposures, cigarette smoking and cocaine use, and placenta previa. " 03/01/2003 - "Advancing maternal age, multiparity, previous Cesarean delivery and abortion, smoking and cocaine use during pregnancy, and male fetuses all conferred increased risk for placenta previa. " 11/01/1997 - "After the effects of other variables were adjusted for, maternal cocaine use was an independent risk factor for placenta previa (adjusted odds ratio = 4.39, 95% confidence interval 1.17 to 16.4). " 11/01/1997 - "Multiple logistic regression was performed to assess the association between cocaine and placenta previa while we controlled for other variables. " 11/01/1997 - "Data on antecedent maternal cocaine use, as well as other potential risk factors for placenta previa, were obtained from a review of the prenatal chart and the hospital record. "
6.	MicroRNAs (MicroRNA)IBA 12/01/2015 - "The aim of this study was to clarify the association between placenta previa and circulating levels of cell-free pregnancy-associated placenta-specific microRNAs (miRNAs) in maternal plasma. "
7.	Vasopressins (Vasopressin)IBA 05/01/2014 - "The aim of this study was to evaluate the effect of local injection of vasopressin on blood loss and secondary impact on complications during cesarean section in patients with placenta previa. " 05/01/2014 - "Local injection of vasopressin reduces the blood loss during cesarean section in placenta previa."
8.	ParaffinIBA 02/01/2015 - "The paraffin blocks of placental tissues, which were obtained from the patients who underwent hysterectomy for placenta previa percreta (n = 12, gestational age > 28 weeks), from legal abortions (n = 12, gestational age < 10 weeks), and of cesarean deliveries with the indication of previous cesarean section, without any complication (n = 12, gestational age > 38 weeks), between January 2011 and April 2013, were included into the study. "
9.	HormonesIBA 06/01/2015 - "The purpose of this study was to examine the levels of hormones in umbilical vein blood that affect the neonatal respiratory function in cases of placenta previa and to evaluate the impact of warning bleeding on the hormone levels and neonatal respiratory outcomes such as respiratory distress syndrome (RDS) and transient tachypnea of the newborn (TTN). "
10.	Complement System Proteins (Complement)IBA 07/01/1992 - "Our study shows that transperineal sonography is a valuable technique to complement transabdominal sonography for detection of placenta previa during the third trimester of pregnancy. "

Therapies and Procedures

1.	Cesarean Section (Caesarean Section) 08/01/1998 - " The incidence of placenta praevia was significantly greater in women with a history of cesarean section than in those without such a history (1.87% and 0.25%, respectively; p 0.0001). " 09/01/2014 - "This study included 110 singleton pregnant women with placenta previa delivered by cesarean section (CS) from July 2011 to November 2013. " 01/01/2012 - "The aim of this study was to compare maternal and perinatal adverse outcomes between groups of placenta previa (PP) with and without previous cesarean section (CS). " 11/01/2011 - "Estimates of the increased risk of maternal complications after caesarean section posed by placenta praevia differ between studies and may not reflect current practice. " 08/01/2011 - "An overall increase in rate of PPH over the study period (OR 1.029; 95% CI 1.024 to 1.034 per year) disappeared (OR 0.995; 95% CI 0.988 to 1.001 per year) after inclusion of maternal age, parity, prior Caesarean section, labour induction and augmentation, placenta previa or low-lying placenta, and abnormal placenta, with most of the reduction attributable to rises in previous Caesarean section and labour augmentation. "
2.	General Anesthesia 02/01/2012 - "Mostly general anesthesia was preferred in the parturients with placenta previa (86.2%, 56/65). " 06/01/1999 - "In women with placenta previa, general anesthesia increased intraoperative blood loss and the need for blood transfusion. " 01/01/2003 - "We concluded that epidural anesthesia is superior to general anesthesia in elective cesarean section for grade 4 placenta previa with regard to maternal hemodynamics and blood loss. " 02/01/2012 - "We found that general anesthesia was our method of preference for placenta previa as we wished to avoid the risk of bleeding. " 10/01/2006 - "Among repeat cesareans, the risk was increased by general anesthesia (OR 7.2, CI 5.9-8.7), a history of five or more prior cesareans (OR 7.6, CI 4.0-14.3), placenta previa (OR 15.9, CI 12.0-21.0), and severe preoperative anemia (OR 19.9, CI 14.5-27.2). "
3.	Epidural Anesthesia 01/01/2003 - "This prospective randomized trial was organized to compare the maternal hemodynamics, blood loss and neonatal outcome of general versus epidural anesthesia for cesarean section with the diagnosis of grade 4 placenta previa. " 01/01/2003 - "Comparison of general and epidural anesthesia in elective cesarean section for placenta previa totalis: maternal hemodynamics, blood loss and neonatal outcome." 01/01/2003 - "We concluded that epidural anesthesia is superior to general anesthesia in elective cesarean section for grade 4 placenta previa with regard to maternal hemodynamics and blood loss. " 10/01/2014 - "We describe the case of a 40-year-old woman (gravida 0, para 0) with placenta previa totalis and uterine myomas who underwent intraoperative UAE, which was preoperatively planned at the strong recommendation of the anesthesiologist, immediately after delivery of a fetus and before removal of the placenta during cesarean delivery under spinal-epidural anesthesia. " 10/01/2009 - "[Epidural anesthesia for five caesarian sections in patients with placenta previa percreta combined with placenta accreta]."
4.	Cervical Cerclage 04/01/2006 - "Cervical cerclage in expectant management of placenta previa." 07/01/1998 - "Cervical cerclage does not appear to be an adequate alternative for the management of placenta previa." 07/01/1998 - "Thirty-nine pregnant women with an initial diagnosis of placenta previa at 24 to 30 weeks' gestation were randomly assigned to cervical cerclage (n = 19) or conservative management (n = 20). " 07/01/1998 - "Our purpose was to determine whether cervical cerclage reduces the maternal and neonatal morbidity in women with placenta previa. " 07/01/1998 - "Cervical cerclage: an alternative for the management of placenta previa?"
5.	Balloon Occlusion 02/01/2015 - "Temporary balloon occlusion of the internal iliac artery before uterine incision during cesarean delivery could potentially reduce blood loss among patients with anterior placenta previa. " 10/01/2014 - "Successful use of BT-Cath(®) balloon tamponade in the management of postpartum haemorrhage due to placenta previa." 12/01/2012 - "Intraoperative aorta balloon occlusion: fertility preservation in patients with placenta previa accreta/increta." 01/01/2012 - "Transfundal uterine incision performed with prophylactic common iliac artery balloon occlusion for patient with placenta previa totalis." 08/01/2011 - "Post-partum haemorrhage from the lower uterine segment secondary to placenta praevia/accreta: successful conservative management with Foley balloon tamponade."