Immune reconstitution inflammatory syndrome associated with Kaposi sarcoma during potent antiretroviral therapy.

Abstract

Rapidly progressive Kaposi sarcoma (KS) lesions with lymphadenopathy and tissue swelling occurred in a patient during antiretroviral treatment, despite an increased CD4(+) lymphocyte count and decreased HIV-1 level and KS-associated herpesvirus replication, suggesting immune reconstitution inflammatory syndrome. Inflammation resolved coincident with decreases in the CD4(+) lymphocyte count during paclitaxel treatment, whereas KS cleared only after prolonged antiretroviral therapy and chemotherapy.

• Authors: Elizabeth Connick, Madeleine A Kane, Irene E White, John Ryder, Thomas B Campbell
• Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 39 Issue 12 Pg. 1852-5 (Dec 15 2004) ISSN: 1537-6591 [Electronic] United States
• PMID: 15578411 (Publication Type: Case Reports, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• DNA, Viral
• Paclitaxel

Topics

• Adult
• Antiretroviral Therapy, Highly Active (adverse effects)
• CD4 Lymphocyte Count
• DNA, Viral (blood)
• Female
• HIV Infections (complications)
• HIV-1 (immunology, physiology)
• Herpesvirus 8, Human (genetics, physiology)
• Humans
• Immune System Diseases (blood, etiology, immunology)
• Inflammation
• Male
• Paclitaxel (therapeutic use)
• Sarcoma, Kaposi (blood, etiology, immunology, virology)
• Syndrome
• Viral Load