Abstract | OBJECTIVES: There have been many studies suggesting that localized scleroderma has a strong autoimmune background, although the lesions are usually limited to the skin and subcutaneous tissue. Here we summarize previous data on the autoimmunity of localized scleroderma, mostly published in the last two decades, because there has not been a review paper summarizing autoimmunity in this disorder. METHODS: RESULTS: CONCLUSIONS: Many previous studies conclude that localized scleroderma involves autoimmune abnormalities and is one of the organ-specific autoimmune disorders targeting mainly skin, although the types of autoimmune abnormality are different from systemic sclerosis.
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Authors | K Takehara, S Sato |
Journal | Rheumatology (Oxford, England)
(Rheumatology (Oxford))
Vol. 44
Issue 3
Pg. 274-9
(Mar 2005)
ISSN: 1462-0324 [Print] England |
PMID | 15561734
(Publication Type: Journal Article, Review)
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Chemical References |
- Antibodies, Antinuclear
- Antibodies, Antiphospholipid
- Antigens, Surface
- Autoantibodies
- Cell Adhesion Molecules
- Cytokines
- DNA, Single-Stranded
- Histones
- Receptors, Cytokine
- Rheumatoid Factor
- DNA Topoisomerases, Type II
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Topics |
- Antibodies, Antinuclear
(immunology)
- Antibodies, Antiphospholipid
(immunology)
- Antigens, Surface
(immunology)
- Autoantibodies
- Autoimmune Diseases
(immunology)
- Cell Adhesion Molecules
(immunology)
- Cytokines
(immunology)
- DNA Topoisomerases, Type II
(immunology)
- DNA, Single-Stranded
(immunology)
- Histones
(immunology)
- Humans
- Receptors, Cytokine
(immunology)
- Rheumatoid Factor
(immunology)
- Scleroderma, Localized
(immunology)
- Solubility
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