Gonadotropin-releasing hormone receptor expression in endometrial stromal sarcomas: an immunohistochemical study.

Abstract

Gonadotropin-releasing hormone and its receptors have been identified in several human malignancies. We evaluated gonadotropin-releasing hormone receptor expression in 30 primary and recurrent endometrial stromal sarcomas. Archival formalin-fixed and paraffin-embedded material was analyzed immunohistochemically with antisera to gonadotropin-releasing hormone receptor type I and gonadotropin-releasing hormone receptor type II using the peroxidase-antiperoxidase method. Gonadotropin-releasing hormone receptor types I and II were demonstrated in most primary endometrial stromal sarcomas in varying intensity and percentage (range, 10-100%). The staining pattern was either diffuse cytoplasmic or granular/vesicular in perinuclear distribution. Recurrences stained stronger than primary tumors. The demonstration of gonadotropin-releasing hormone receptors I and II expression in endometrial stromal sarcomas may be a rationale for a clinical study of gonadotropin-releasing hormone analogs in the treatment of women with endometrial stromal sarcomas.

• Authors: Olaf Reich, Francisco F Nogales, Sigrid Regauer
• Journal: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc (Mod Pathol) Vol. 18 Issue 4 Pg. 573-6 (Apr 2005) ISSN: 0893-3952 [Print] United States
• PMID: 15529183 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Receptors, LHRH

Topics

• Female
• Humans
• Immunohistochemistry
• Neoplasm Metastasis
• Neoplasm Recurrence, Local
• Receptors, LHRH (biosynthesis)
• Sarcoma, Endometrial Stromal (metabolism, pathology)