Abstract |
A series of natural stilbenoids, pinosylvin and its derivatives, were synthesized and evaluated for the inhibitory activity of prostaglandin E(2) production in lipopolysaccharide-induced RAW 264.7 cells. Potential inhibitors, including 3,5-dimethoxy-trans-stilbene and 3-hydroxy-5-benzyloxy-trans-stilbene, have been newly identified, and thus providing chemical leads for the further development of anti-inflammatory or cancer chemopreventive agents.
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Authors | Eun-Jung Park, Hye-Young Min, Yong-Hyun Ahn, Cheol-Man Bae, Jae-Ho Pyee, Sang Kook Lee |
Journal | Bioorganic & medicinal chemistry letters
(Bioorg Med Chem Lett)
Vol. 14
Issue 23
Pg. 5895-8
(Dec 06 2004)
ISSN: 0960-894X [Print] England |
PMID | 15501064
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Lipopolysaccharides
- Stilbenes
- pinosylvin
- Dinoprostone
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Topics |
- Animals
- Cell Line
- Dinoprostone
(antagonists & inhibitors, biosynthesis)
- Lipopolysaccharides
(pharmacology)
- Macrophages
(drug effects, metabolism)
- Mice
- Stilbenes
(chemical synthesis, pharmacology)
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