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Synthesis and inhibitory effects of pinosylvin derivatives on prostaglandin E2 production in lipopolysaccharide-induced mouse macrophage cells.

Abstract
A series of natural stilbenoids, pinosylvin and its derivatives, were synthesized and evaluated for the inhibitory activity of prostaglandin E(2) production in lipopolysaccharide-induced RAW 264.7 cells. Potential inhibitors, including 3,5-dimethoxy-trans-stilbene and 3-hydroxy-5-benzyloxy-trans-stilbene, have been newly identified, and thus providing chemical leads for the further development of anti-inflammatory or cancer chemopreventive agents.
AuthorsEun-Jung Park, Hye-Young Min, Yong-Hyun Ahn, Cheol-Man Bae, Jae-Ho Pyee, Sang Kook Lee
JournalBioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 14 Issue 23 Pg. 5895-8 (Dec 06 2004) ISSN: 0960-894X [Print] England
PMID15501064 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Lipopolysaccharides
  • Stilbenes
  • pinosylvin
  • Dinoprostone
Topics
  • Animals
  • Cell Line
  • Dinoprostone (antagonists & inhibitors, biosynthesis)
  • Lipopolysaccharides (pharmacology)
  • Macrophages (drug effects, metabolism)
  • Mice
  • Stilbenes (chemical synthesis, pharmacology)

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