Abstract | OBJECTIVE: METHODS: Adult male Sprague-Dawley rats were injured using the 2-metre impact acceleration model of diffuse TBI. At 30 min after injury, animals were administered with either 250 micromoles/kg i.v. MgSO(4), MgGl(2), or equal volume saline vehicle. Thereafter, animals were assessed for motor and cognitive outcome using the rotarod and Barnes maze, respectively, or their brains removed at 3 days after TBI and used for histological examination. RESULTS: Treatment with either magnesium salt significantly improved functional outcome as compared to vehicle treated controls. Similarly, treatment with either magnesium salt attenuated the degree of histological dark cell change at 3 days after TBI relative to the vehicle treated animals. There were no significant differences between the magnesium treated groups. CONCLUSIONS: We conclude that MgSO(4) and MgGl(2) are equally neuroprotective following TBI. Our results suggest that MgGl(2) may only be more effective in conditions that produce ischaemia, where high concentrations of reactive oxygen species are generated.
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Authors | Renee J Turner, K W Dasilva, C O'Connor, Corinna van den Heuvel, Robert Vink |
Journal | Journal of the American College of Nutrition
(J Am Coll Nutr)
Vol. 23
Issue 5
Pg. 541S-544S
(Oct 2004)
ISSN: 0731-5724 [Print] United States |
PMID | 15466961
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Gluconates
- Neuroprotective Agents
- Magnesium Sulfate
- Magnesium
- gluconic acid
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Topics |
- Animals
- Brain
(metabolism)
- Brain Injuries
(metabolism)
- Cognition
(drug effects, physiology)
- Gluconates
(pharmacology)
- Magnesium
(metabolism)
- Magnesium Sulfate
(pharmacology)
- Male
- Maze Learning
(drug effects, physiology)
- Motor Activity
(drug effects, physiology)
- Neuroprotective Agents
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Rotarod Performance Test
- Treatment Outcome
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