Abstract | PURPOSE: To test the effect of aqueous eye drops containing a high concentration of disulfiram (DSF) in a cyclodextrin- based drug delivery system. This system increases both the drug solubility in aqueous eye drops and the permeability of drug into the rabbit eye, by the formation of a drug- cyclodextrin inclusion complex, and so enhances the ocular bioavailability and anti- cataract effect of DSF. METHODS: RESULTS: CONCLUSIONS: The cyclodextrin-based drug delivery system enhances both the solubility of DSF in aqueous eye drops and permeability of the drug into the rabbit eye. DSF ocular bioavailability in rabbit aqueous humor exceeded those reported for the DSF ophthalmic preparation. DSF eye drops effectively prevent the development of selenite-induced cataracts.
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Authors | Siling Wang, Dexin Li, Yoshimasa Ito, Tomohiro Nabekura, Shujun Wang, Jinghai Zhang, Chunfu Wu |
Journal | Current eye research
(Curr Eye Res)
Vol. 29
Issue 1
Pg. 51-8
(Jul 2004)
ISSN: 0271-3683 [Print] England |
PMID | 15370367
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Ophthalmic Solutions
- beta-Cyclodextrins
- 2-Hydroxypropyl-beta-cyclodextrin
- Sodium Selenite
- Disulfiram
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Topics |
- 2-Hydroxypropyl-beta-cyclodextrin
- Administration, Topical
- Animals
- Aqueous Humor
(metabolism)
- Biological Availability
- Cataract
(chemically induced, metabolism, prevention & control)
- Chromatography, High Pressure Liquid
- Cornea
(metabolism)
- Disulfiram
(administration & dosage, pharmacokinetics)
- Drug Delivery Systems
- Female
- Male
- Ophthalmic Solutions
(administration & dosage, pharmacokinetics)
- Permeability
- Rabbits
- Rats
- Rats, Wistar
- Sodium Selenite
(toxicity)
- Solubility
- Spectroscopy, Fourier Transform Infrared
- X-Ray Diffraction
- beta-Cyclodextrins
(administration & dosage, pharmacokinetics)
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