Cytochrome P450 1B1 gene polymorphisms and postmenopausal endometrial cancer risk.

Abstract	Estrogen unopposed by progestins is a key factor in endometrial cancer etiology. Cytochrome P450 1B1 (CYP1B1), responsible for the 4-hydroxylation of estrogen, may be important in endometrial carcinogenesis, either as a regulator of estrogen availability or as a producer of potentially genotoxic estrogen metabolites. We investigated the association of CYP1B1 genotype and endometrial cancer risk in a population-based case-control study of postmenopausal Swedish women. We used the Expectation-Maximization algorithm to estimate the haplotype frequencies in the population and calculated odds ratios and 95% confidence intervals from conditional logistic regression models. In stratified analysis, we investigated the possible effects of CYP1B1 genotype on endometrial cancer risk in subgroups defined primarily by menopausal hormone use and also by body mass index, smoking, use of combined oral contraceptives, and family history. We genotyped 689 cases and 1,549 controls for the CYP1B1 single nucleotide polymorphisms m2, m3, and m4 and estimated the haplotype frequencies among controls to 0.086, 0.291, 0.452, and 0.169 for the CYP1B11, CYP1B12, CYP1B13, and CYP1B14 alleles, respectively. We found no evidence for an overall association between CYP1B1 genotype and endometrial cancer risk, nor was there any clear indication of gene-environment interaction.
Authors	Tove Rylander-Rudqvist, Sara Wedrén, Gudrun Jonasdottir, Susanne Ahlberg, Elisabete Weiderpass, Ingemar Persson, Magnus Ingelman-Sundberg
Journal	Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (Cancer Epidemiol Biomarkers Prev) Vol. 13 Issue 9 Pg. 1515-20 (Sep 2004) ISSN: 1055-9965 [Print] United States
PMID	15342454 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Aryl Hydrocarbon Hydroxylases CYP1B1 protein, human Cytochrome P-450 CYP1B1
Topics	Aged Aryl Hydrocarbon Hydroxylases (genetics) Case-Control Studies Cytochrome P-450 CYP1B1 Endometrial Neoplasms (epidemiology, genetics) Female Gene Frequency (genetics) Genotype Haplotypes (genetics) Hormone Replacement Therapy Humans Logistic Models Middle Aged Odds Ratio Polymorphism, Single Nucleotide Postmenopause Risk Statistics as Topic Sweden

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