Lipid-altering changes and pleiotropic effects of atorvastatin in patients with hypercholesterolemia.

Abstract	In this prospective study, we found beneficial short-term effects from atorvastatin therapy, including effects on low-density lipoprotein subfractions and remnant-like lipoprotein particle cholesterol, antioxidant effects, and alterations in endothelial function that may be important in early benefit from statin therapy; some effects would support much earlier benefit than previously reported. We also found long-term effects of atorvastatin, including decreased plasminogen activator inhibitor type-1 and additional significant alterations in low-density lipoprotein subfractions and endothelial function, supporting benefits from continuous long-term atorvastatin therapy beyond early reversal of hypercholesterolemia.
Authors	Koichi Sakabe, Nobuo Fukuda, Katsunori Wakayama, Teru Nada, Hisanori Shinohara, Yoshiyuki Tamura
Journal	The American journal of cardiology (Am J Cardiol) Vol. 94 Issue 4 Pg. 497-500 (Aug 15 2004) ISSN: 0002-9149 [Print] United States
PMID	15325939 (Publication Type: Journal Article)
Chemical References	Anticholesteremic Agents Cholesterol, HDL Cholesterol, LDL Heptanoic Acids Hydroxymethylglutaryl-CoA Reductase Inhibitors Plasminogen Activator Inhibitor 1 Pyrroles Thiobarbituric Acid Reactive Substances Triglycerides Cholesterol Atorvastatin
Topics	Adult Aged Anticholesteremic Agents (adverse effects, therapeutic use) Atorvastatin Basilar Artery (drug effects) Cholesterol (blood) Cholesterol, HDL (blood) Cholesterol, LDL (blood) Endothelium, Vascular (drug effects) Female Fibrinolysis (drug effects) Follow-Up Studies Heptanoic Acids (adverse effects, therapeutic use) Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors (adverse effects, therapeutic use) Hypercholesterolemia (blood, drug therapy) Long-Term Care Male Middle Aged Plasminogen Activator Inhibitor 1 (blood) Prospective Studies Pyrroles (adverse effects, therapeutic use) Thiobarbituric Acid Reactive Substances (metabolism) Treatment Outcome Triglycerides (blood) Vasodilation (drug effects)

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