Understanding cystic-fibrosis-related diabetes: best thought of as insulin deficiency?

Abstract

The limited available evidence supports the use of insulin treatment in CFRD. This fits with the dominant problem in CFRD being insulin deficiency and progressive beta cell dysfunction, making tablets that stimulate the beta cell unlikely to be a successful strategy. It is possible that patients with IGT or CFRD with moderate hyperglycaemia (e.g. relative preservation of fasting glucose) may initially respond to beta cell secretagogues. A large randomized prospective trial in the USA should answer this point in the next few years.

• Authors: Lee Dobson, Christopher D Sheldon, Andrew T Hattersley
• Journal: Journal of the Royal Society of Medicine (J R Soc Med) Vol. 97 Suppl 44 Pg. 26-35 ( 2004) ISSN: 0141-0768 [Print] England
• PMID: 15239291 (Publication Type: Journal Article, Review)

Chemical References

• Blood Glucose
• Hypoglycemic Agents
• Insulin

Topics

• Blood Glucose (analysis)
• Cystic Fibrosis (complications)
• Diabetes Mellitus (diagnosis, etiology, therapy)
• Glucose Tolerance Test (methods)
• Humans
• Hypoglycemic Agents (therapeutic use)
• Insulin (deficiency)