[Idiopathic membranous nephropathy associated with anti-calcineurin toxicity. Prognosis and other immunosuppressive treatments].

Abstract

A 32-year-old male patient was admitted at our department presenting microhematuria and full nephrotic syndrome in April 1995. A percutaneous kidney biopsy showed a stage I-lI membranous nephropathy and an eight-week course with oral prednisone was initiated without response. Then, oral cyclosporine A (3.5 mg/kg/day) was given and after 5 weeks of treatment, remission of the nephrotic syndrome was observed but creatinine raised to 1.6 mg/dl, normalizing after reducing the dose of cyclosporine A. We discuss the settings, prognostic and therapeutic alternatives for idiopathic membranous nephropathy.

• Authors: A B Muñoz Díaz, P Aguilar
• Journal: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia (Nefrologia) Vol. 24 Suppl 3 Pg. 76-80 ( 2004) ISSN: 0211-6995 [Print] Spain
• Vernacular Title: Nefropatía membranosa idiopática asociada a toxicidad por anticalcineurínicos.
• PMID: 15219075 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Angiotensin-Converting Enzyme Inhibitors
• Antihypertensive Agents
• Calcineurin Inhibitors
• Calcium Channel Blockers
• Hypolipidemic Agents
• Immunosuppressive Agents
• Cyclosporine
• Lovastatin
• Creatinine
• Verapamil
• Lisinopril
• Prednisone

Topics

• Adult
• Angiotensin-Converting Enzyme Inhibitors (therapeutic use)
• Antihypertensive Agents (therapeutic use)
• Calcineurin Inhibitors
• Calcium Channel Blockers (therapeutic use)
• Creatinine (blood)
• Cyclosporine (adverse effects, therapeutic use)
• Drug Therapy, Combination
• Glomerulonephritis, Membranous (complications)
• Humans
• Hypercholesterolemia (complications, drug therapy)
• Hypertension (complications, drug therapy)
• Hypolipidemic Agents (therapeutic use)
• Immunosuppressive Agents (adverse effects, therapeutic use)
• Kidney Diseases (chemically induced)
• Lisinopril (therapeutic use)
• Lovastatin (therapeutic use)
• Male
• Nephrotic Syndrome (drug therapy, etiology)
• Prednisone (therapeutic use)
• Recurrence
• Verapamil (therapeutic use)