Acupuncture suppresses intrastriatal hemorrhage-induced apoptotic neuronal cell death in rats.

Abstract

Intracerebral hemorrhage is one of the most devastating types of stroke. In the present study, the effect of acupuncture on intrastriatal hemorrhage-induced neuronal cell death in rats was investigated via Nissl staining, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assay, and immunohistochemistry for caspase-3. The present results showed that lesion size and apoptotic neuronal cell death in the striatum were significantly increased following intrastriatal hemorrhage in rats and that acupunctural treatment at the Zusanli acupoint suppressed the hemorrhage-induced increase in lesion size and apoptotic neuronal cell death in the striatum. In the present study, it can be suggested that acupunctural treatment, especially at the Zusanli acupoint, may aid in the recovery following central nervous system sequellae following intracerebral hemorrhage.

• Authors: Nam-Hun Cho, Jae-Dong Lee, Byung-Shik Cheong, Do-Young Choi, Hyun-Kyung Chang, Taeck-Hyun Lee, Min-Chul Shin, Mal-Soon Shin, Jongseok Lee, Chang-Ju Kim
• Journal: Neuroscience letters (Neurosci Lett) Vol. 362 Issue 2 Pg. 141-5 (May 20 2004) ISSN: 0304-3940 [Print] Ireland
• PMID: 15193772 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2004 Elsevier Ireland Ltd.

Topics

• Acupuncture Therapy (methods)
• Animals
• Apoptosis (physiology)
• Cell Death (physiology)
• Cerebral Hemorrhage (pathology, prevention & control)
• Corpus Striatum (pathology)
• Male
• Neurons (pathology, physiology)
• Rats
• Rats, Sprague-Dawley