Expression of MUC1, MUC2, MUC5AC, and MUC6 in atypical adenomatous hyperplasia, bronchioloalveolar carcinoma, adenocarcinoma with mixed subtypes, and mucinous bronchioloalveolar carcinoma of the lung.

Abstract	We examined the expression of MUC1, MUC2, MUC5AC, and MUC6 by immunohistochemical staining in atypical adenomatous hyperplasia (AAH), bronchioloalveolar carcinoma (BAC), and adenocarcinoma with mixed subtypes (MX) to study the association between the biologic features of adenocarcinoma of the lung and mucin expression. MUC1 expression was decreased significantly in the progression from AAH through BAC to MX, while the levels of expression of MUC2, MUC5AC, MUC6, and depolarized MUC1 were increased significantly. Alterations in the expression of depolarized MUC1, MUC5AC, and MUC6 were correlated significantly with p53 gene abnormalities. Depolarized MUC1 expression also was correlated significantly with Ki-67 expression, and down-regulation of MUC1 expression and up-regulation of MUC6 expression were correlated significantly with tumor size. Our results suggest that the expression of these mucins might be associated with the progression of adenocarcinoma of the lung.
Authors	Hirokazu Awaya, Yukio Takeshima, Masahiro Yamasaki, Kouki Inai
Journal	American journal of clinical pathology (Am J Clin Pathol) Vol. 121 Issue 5 Pg. 644-53 (May 2004) ISSN: 0002-9173 [Print] England
PMID	15151204 (Publication Type: Journal Article)
Chemical References	DNA, Neoplasm Ki-67 Antigen MUC2 protein, human MUC5AC protein, human MUC6 protein, human Mucin 5AC Mucin-1 Mucin-2 Mucin-6 Mucins Tumor Suppressor Protein p53
Topics	Adenocarcinoma, Bronchiolo-Alveolar (genetics, metabolism, pathology) Adenocarcinoma, Mucinous (genetics, metabolism, pathology) Adenoma (genetics, metabolism, pathology) Adult Aged Aged, 80 and over DNA Mutational Analysis DNA, Neoplasm (analysis) Female Genes, p53 Humans Hyperplasia Immunoenzyme Techniques Ki-67 Antigen (metabolism) Lung Neoplasms (genetics, metabolism, pathology) Male Middle Aged Mucin 5AC Mucin-1 (metabolism) Mucin-2 Mucin-6 Mucins (metabolism) Mutation Tumor Suppressor Protein p53 (genetics, metabolism)

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