Abstract | PURPOSE: PATIENTS AND METHODS: We analyzed a group of patients who previously received doxorubicin-based chemotherapy for lymphoma. Echocardiograms were performed at least 5 years after therapy with anthracyclines. Clinical cardiomyopathy was defined by the presence of clinical signs of congestive heart failure (CHF). Subclinical cardiomyopathy was defined by decrease of left ventricular fractional shortening (FS) without clinical signs of CHF. Cumulative dose of doxorubicin, male sex, older age, relapse, radiotherapy (mediastinal or total-body irradiation), autologous stem-cell transplantation, high-dose cyclophosphamide, and cardiovascular risk factors ( hypertension, diabetes, hypercholesterolemia, familial history of cardiac disease, being overweight, and smoking history) were evaluated as potential risk factors for the development of cardiac dysfunction. RESULTS: Of 141 assessable patients (median age, 54 years; median cumulative dose of doxorubicin, 300 mg/m(2)), only one developed CHF. Criteria of subclinical cardiomyopathy were found in 39 patients. In multivariate analysis, factors that contributed to decreased FS were male sex (P <.01), older age (P <.01), higher cumulative dose of doxorubicin or association with another anthracycline (P =.04), radiotherapy (P =.04), and being overweight (P =.04). CONCLUSION:
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Authors | O Hequet, Q H Le, I Moullet, E Pauli, G Salles, D Espinouse, C Dumontet, C Thieblemont, P Arnaud, D Antal, F Bouafia, B Coiffier |
Journal | Journal of clinical oncology : official journal of the American Society of Clinical Oncology
(J Clin Oncol)
Vol. 22
Issue 10
Pg. 1864-71
(May 15 2004)
ISSN: 0732-183X [Print] United States |
PMID | 15143078
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibiotics, Antineoplastic
- Doxorubicin
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antibiotics, Antineoplastic
(adverse effects)
- Cardiomyopathies
(chemically induced, epidemiology)
- Doxorubicin
(adverse effects)
- Electrocardiography
- Female
- France
(epidemiology)
- Humans
- Lymphoma
(drug therapy)
- Male
- Middle Aged
- Risk Factors
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