Abstract |
The aim of this study was to investigate the relationship between the biochemical markers of arthritis and the radiographic grading of osteoarthritis (OA) in knees. Seventy-one women aged 49-85 years with knee OA were studied. Anterior-posterior knee radiographs and hand radiographs were taken in all patients. The radiographic grading of OA in the knee was performed by using the Kellgren-Lawrence criteria and the joint space width. The 71 patients with knee OA were divided into two groups: 37 patients exhibiting generalized osteoarthritis (GOA) and 34 non-GOA patients, according to the grading of their hand radiograph. C-reactive protein (CRP), urinary pyridinoline, YKL-40, plasma matrix metalloproteinase (MMP)-3, MMP-9 and tissue inhibitor of metalloproteinases (TIMP)-1 were measured as the biochemical markers of arthritis. The radiographic grading with the Kellgren-Lawrence scale revealed a significant relationship to the joint space width (P = 0.003): the joint space width decreased with increasing Kellgren-Lawrence grade. All biochemical markers had negative correlations with the joint space width, but only urinary pyridinoline had a significant correlation (P = 0.039). Pyridinoline (P = 0.034) and TIMP-1 (P = 0.017) also exhibited a significant relationship to the Kellgren-Lawrence grade. In GOA evaluations, the joint space width did not differ between GOA and non-GOA patients. CRP, pyridinoline, YKL-40 and MMP-3 levels were significantly greater in GOA patients than in non-GOA patients. CRP, pyridinoline, YKL-40, MMP-3 and TIMP-1 levels each related to at least one of the radiographic gradings. Furthermore, pyridinoline related to every type of radiographic grading examined in the present study.
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Authors | Masaaki Takahashi, Kenichi Naito, Masashi Abe, Tomokazu Sawada, Akira Nagano |
Journal | Arthritis research & therapy
(Arthritis Res Ther)
Vol. 6
Issue 3
Pg. R208-12
( 2004)
ISSN: 1478-6362 [Electronic] England |
PMID | 15142266
(Publication Type: Journal Article)
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Chemical References |
- Adipokines
- Amino Acids
- Biomarkers
- CHI3L1 protein, human
- Chitinase-3-Like Protein 1
- Glycoproteins
- Lectins
- Tissue Inhibitor of Metalloproteinase-1
- pyridinoline
- C-Reactive Protein
- Matrix Metalloproteinase 3
- Matrix Metalloproteinase 9
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Topics |
- Adipokines
- Aged
- Aged, 80 and over
- Amino Acids
(urine)
- Biomarkers
(blood, urine)
- C-Reactive Protein
(metabolism)
- Chitinase-3-Like Protein 1
- Disease Progression
- Female
- Glycoproteins
(blood)
- Hand
(pathology)
- Humans
- Lectins
- Matrix Metalloproteinase 3
(blood)
- Matrix Metalloproteinase 9
(blood)
- Middle Aged
- Osteoarthritis
(blood, diagnostic imaging, urine)
- Osteoarthritis, Knee
(blood, diagnostic imaging, urine)
- Postmenopause
(blood, metabolism, urine)
- Radiography
- Spinal Osteophytosis
(blood, diagnostic imaging, urine)
- Tissue Inhibitor of Metalloproteinase-1
(blood)
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