Minor histocompatibility antigens--big in tumour therapy.

Abstract	Technical advances combined with the deciphering of the human genome have facilitated the identification of the molecular nature of human minor histocompatibility (H) antigens. To date, it is believed that minor H antigens result from just any polymorphic protein, regardless of their functional properties. A closer look at the first series of autosomally encoded human minor H proteins reveals a striking functional relationship. Here, we propose that T cells generated after HLA-identical stem cell transplantation (SCT) for malignancies are likely to be directed towards peptides derived from minor H proteins involved in tumourigenesis. This novel insight has important consequences in the search for, and the use of, minor H antigens as immunotherapeutics in stem-cell-based immunotherapy of haematological malignancies and solid tumours.
Authors	Eric Spierings, Brigitte Wieles, Els Goulmy
Journal	Trends in immunology (Trends Immunol) Vol. 25 Issue 2 Pg. 56-60 (Feb 2004) ISSN: 1471-4906 [Print] England
PMID	15102363 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review)
Chemical References	A Kinase Anchor Proteins AKAP13 protein, human Adaptor Proteins, Signal Transducing BCL2-related protein A1 GTPase-Activating Proteins Guanine Nucleotide Exchange Factors HA-1 antigen HA-2 antigen HLA-B Antigens HMHB1 protein, human Minor Histocompatibility Antigens Neoplasm Proteins Oligopeptides PUM3 protein, human Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcl-2 rho GTP-Binding Proteins
Topics	A Kinase Anchor Proteins Adaptor Proteins, Signal Transducing GTPase-Activating Proteins (physiology) Guanine Nucleotide Exchange Factors (physiology) HLA-B Antigens (physiology) Humans Minor Histocompatibility Antigens (physiology, therapeutic use) Models, Biological Neoplasm Proteins (physiology) Neoplasms (immunology, physiopathology, therapy) Oligopeptides (physiology) Proto-Oncogene Proteins (physiology) Proto-Oncogene Proteins c-bcl-2 (physiology) Stem Cell Transplantation T-Lymphocytes (immunology) Transplantation Immunology rho GTP-Binding Proteins (physiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!