Abstract | BACKGROUND: PATIENTS AND METHODS: Twenty-nine patients on chronic HD treatment were randomly assigned to 2 groups in a 3-period 2-treatment design with low flux (A)--high flux (B)--low flux (A) for group I and B-A-B for group II, 6 weeks each period. The following parameters were measured in pre- and postdialytic serum samples at baseline and the end of each period: total serum fluorescence, Nepsilon- carboxymethyllysine (CML), free and protein-bound pentosidine, tHcy, Cysta and DMG. RESULTS: There was increased removal of free pentosidine during high-flux HD treatment compared to low-flux HD treatment, attaining significance between the second and third treatment periods (group 1: 86.0 +/- 4.7% vs. 79.2 +/- 8.8%, p = 0.007; group II: 84.0 +/- 6.3% vs. 79.8 +/- 9.8%, p = 0.049 for high vs. low flux). The intradialytic reduction rates for total serum fluorescence, tHcy, Cysta, DMG did not differ between high- and low-flux HD treatment. Protein-bound pentosidine and CML did not decrease during the dialysis sessions, neither with high-flux nor with low-flux HD membrane. Despite a strong decrease during single HD session, the predialytic levels of free pentosidine, tHcy, Cysta and DMG remained unchanged during the study period both for high- and low-flux HD treatment. CONCLUSION: The more pronounced effect of high-flux dialysis on the removal rate of free pentosidine, found in this randomized crossover study, could not translate into a significant difference in predialysis levels after a 6-week treatment period. We could not find any differences between polysulfone high- and low-flux membranes for lowering predialytic serum concentrations of the measured AGEs, which are mainly bound on albumin.
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Authors | A Klemm, C Franke, M Busch, A Müller, S Franke, D Lang, J Passlick-Deetjen, G Stein |
Journal | Clinical nephrology
(Clin Nephrol)
Vol. 61
Issue 3
Pg. 191-7
(Mar 2004)
ISSN: 0301-0430 [Print] Germany |
PMID | 15077870
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Glycation End Products, Advanced
- Membranes, Artificial
- Polymers
- Sulfones
- Homocysteine
- polysulfone P 1700
- Cystathionine
- dimethylglycine
- Arginine
- pentosidine
- Lysine
- Sarcosine
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Topics |
- Arginine
(analogs & derivatives, blood)
- Cross-Over Studies
- Cystathionine
(blood)
- Enzyme-Linked Immunosorbent Assay
- Female
- Fluorescence
- Glycation End Products, Advanced
(blood)
- Homocysteine
(metabolism)
- Humans
- Kidneys, Artificial
- Lysine
(analogs & derivatives, blood)
- Male
- Membranes, Artificial
- Middle Aged
- Polymers
- Prospective Studies
- Renal Dialysis
(instrumentation, methods)
- Sarcosine
(analogs & derivatives, blood)
- Sulfones
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