Genetic and acquired thrombotic factors in chronic hepatitis C.

Abstract

OBJECTIVES:

During the progression of chronic liver disease towards cirrhosis, morphological studies have shown a close association between parenchymal remodeling and obliterative lesions of intrahepatic small portal and hepatic veins. These lesions are highly suggestive of intrahepatic thrombotic events, which may have a key role in the pathogenesis of hepatic fibrosis. The aim of the study was to investigate thrombotic risk factors in chronic hepatitis C patients with different extent of liver fibrosis.

METHODS:

The following thrombotic factors were evaluated in 68 hepatitis C patients with prothrombin activity >/= 80% (34 consecutive patients with extensive fibrosis and/or cirrhosis compared with 34 consecutive patients without extensive fibrosis and/or cirrhosis): factor V Leiden, G20210A prothrombin mutation, antithrombin, protein C and S deficiencies, hyperhomocysteinemia, elevated factor VIII level, and lupus anticoagulant.

RESULTS:

Three thrombotic risk factors were significantly more frequent in patients with extensive fibrosis and/or cirrhosis than in those without extensive fibrosis: protein C deficiency present in 14 patients (41%) as compared with three patients (9%), p= 0.004; elevated factor VIII level present in 19 patients (56%) as compared with six patients (18%), p= 0.002; and hyperhomocysteinemia present in 10 patients (29%) as compared with two patients (6%), p= 0.023. The association of two or three prothrombotic factors was present in 19 patients (56%) with extensive fibrosis and/or cirrhosis as compared with one patient (3%) without extensive fibrosis and/or cirrhosis, p < 0.001.

CONCLUSION:

Multiple thrombotic risk factors coexist frequently in patients with extensive fibrosis and early stage of cirrhosis. Their association with local inflammation could favor thrombotic events in the liver micro-circulatory bed.

• Authors: Armelle Poujol-Robert, Olivier Rosmorduc, Lawrence Serfaty, Florence Coulet, Raoul Poupon, Annie Robert
• Journal: The American journal of gastroenterology (Am J Gastroenterol) Vol. 99 Issue 3 Pg. 527-31 (Mar 2004) ISSN: 0002-9270 [Print] United States
• PMID: 15056097 (Publication Type: Journal Article)

Chemical References

• Antithrombins
• Protein C
• Protein S
• Homocysteine
• Factor VIII

Topics

• Adult
• Aged
• Antithrombins (analysis)
• Factor VIII (analysis)
• Female
• Hepatitis C, Chronic (blood, etiology, genetics)
• Homocysteine (blood)
• Humans
• Male
• Middle Aged
• Protein C (analysis)
• Protein S (analysis)
• Risk Factors
• Thrombosis (blood, complications, genetics)