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The role of beta-glucuronidase in induction of apoptosis by genistein combined polysaccharide (GCP) in xenogeneic mice bearing human mammary cancer cells.

Abstract
In order to reveal the mechanisms underlying genistein combined polysaccharide (GCP) inhibition of tumor proliferation, we investigated the effects of GCP on the growth of human breast cancer cells transplanted to athymic nude mice. We further investigated the metabolism of genistein and its association with the beta-glucuronidase activity in tumor and normal tissues.
AuthorsLan Yuan, Chihiro Wagatsuma, Buxiang Sun, Jung-Hwan Kim, Young-Joon Surh
JournalAnnals of the New York Academy of Sciences (Ann N Y Acad Sci) Vol. 1010 Pg. 347-9 (Dec 2003) ISSN: 0077-8923 [Print] United States
PMID15033749 (Publication Type: Journal Article)
Chemical References
  • Polysaccharides
  • genistein combined polysaccharide
  • Genistein
  • Glucuronidase
Topics
  • Animals
  • Apoptosis (drug effects, physiology)
  • Breast Neoplasms (drug therapy, enzymology, pathology)
  • Cell Cycle (drug effects)
  • Cell Division (drug effects)
  • Female
  • Flow Cytometry
  • Genistein (pharmacology)
  • Glucuronidase (metabolism)
  • Humans
  • Mice
  • Polysaccharides (pharmacology)
  • Transplantation, Heterologous

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