[Effect of triple antiretroviral therapy on Tunisian AIDS profile: study of 139 cases].

Abstract

We report a retrospective study to estimate highly active antiretroviral therapy (HAART) effect in 139 HIV infected patients. Four criteria are studied: prevalence of opportunistic infections, CD4 cell count evolution, viral load progression and mortality. Gastrointestinal side effects are the most common clinical adverse reaction (61.1 percent), and hematological side effects are the most common biological adverse reaction (61.2 percent). During the 22.8 months (3 months to 6 years) follow-up average period, CD4 cell counts remained above 500 per cubic millimeter in only 25.8 percent of cases, while 63.5 percent of patients had a viral load below 400 copies per milliliter. During the study on patients receiving HAART, opportunistic infections appeared in 17.3 percent of cases (24 cases) and mortality in 6.4 percent of cases.

• Authors: Fayçal Zouiten, Lamia Ammari, Ahmed Goubantini, Hanène Tiouiri, Amine Slim, Ahmed Maamouri, Badreddine Kilani, Fakher Kanoun, Chekib Marrakchi, Nahed Neifer, Leila Mihoub, Faouzi Jenhani, Mounira Garbouj, Taoufik Ben Chaabane
• Journal: La Tunisie medicale (Tunis Med) Vol. 81 Issue 12 Pg. 956-62 (Dec 2003) ISSN: 0041-4131 [Print] Tunisia
• Vernacular Title: Impact de la trithérapie anti-retrovirale sur le profil evolutif du sideen Tunisien: etude de 139 cas.
• PMID: 14986532 (Publication Type: English Abstract, Journal Article)

Topics

• AIDS-Related Opportunistic Infections (epidemiology)
• Acquired Immunodeficiency Syndrome (complications, drug therapy)
• Adolescent
• Adult
• Aged
• Antiretroviral Therapy, Highly Active
• CD4 Lymphocyte Count
• Child
• Disease Progression
• Female
• Humans
• Incidence
• Infant
• Male
• Middle Aged
• Retrospective Studies
• Tunisia
• Viral Load