Body iron stores in relation to risk of type 2 diabetes in apparently healthy women.
Abstract | CONTEXT: OBJECTIVE: DESIGN, SETTING, AND PARTICIPANTS: Prospective nested case-control study within the Nurses' Health Study cohort. Of the 32 826 women who provided blood samples during 1989-1990 and were free of diagnosed diabetes, cardiovascular disease, and cancer, 698 developed diabetes during 10 years of follow-up. The controls (n = 716) were matched to cases on age, race, and fasting status; and on body mass index (BMI) for cases in the top BMI decile. MAIN OUTCOME MEASURE: RESULTS: Among cases, the mean (SD) concentration of ferritin was significantly higher (109 [105] vs 71.5 [68.7] ng/mL for controls; P<.001 for difference) and the mean (SD) ratio of transferrin receptors to ferritin was significantly lower (102 [205] vs 141 [340], respectively; P =.01). In conditional logistic regression stratified on the matching factors and controlled for BMI and other diabetes risk factors, the multivariate relative risks [RRs] of incident type 2 diabetes across increasing quintiles of ferritin were 1.00, 1.09 (95% confidence interval [CI], 0.70-1.70), 1.26 (95% CI, 0.82-1.95), 1.30 (95% CI, 0.83-2.04), and 2.68 (95% CI, 1.75-4.11) (P<.001 for trend). The RRs across increasing quintiles of transferrin receptors to ferritin ratio were 2.44 (95% CI, 1.61-3.71), 1.00 (95% CI, 0.64-1.56), 1.13 (95% CI, 0.73-1.74), 0.99 (95% CI, 0.64-1.53), and 1.00 (P =.01 for trend). Further adjustment for an inflammatory marker ( C-reactive protein) did not change the results appreciably. The associations persisted within strata defined by levels of BMI, menopausal status, alcohol consumption, and C-reactive protein. CONCLUSION:
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Authors | Rui Jiang, JoAnn E Manson, James B Meigs, Jing Ma, Nader Rifai, Frank B Hu |
Journal | JAMA
(JAMA)
Vol. 291
Issue 6
Pg. 711-7
(Feb 11 2004)
ISSN: 1538-3598 [Electronic] United States |
PMID | 14871914
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Receptors, Transferrin
- Ferritins
- Iron
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Topics |
- Adult
- Case-Control Studies
- Diabetes Mellitus, Type 2
(blood, epidemiology)
- Female
- Ferritins
(blood)
- Humans
- Iron
(blood)
- Iron Overload
- Middle Aged
- Multivariate Analysis
- Prospective Studies
- Receptors, Transferrin
(blood)
- Risk Factors
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