[A case of rectal cancer with distant lymph node metastases completely responding to postoperative chemotherapy with levofolinate combined with 5-fluorouracil].

Abstract

The patient was a 58-year-old female who had a cancer of the rectum with multiple lymph node metastases including paraaortic lymph nodes and Virchow lymph nodes. Abdominoperineal resection was performed palliatively. After the operation, weekly bolus of 5-fluorouracil combined with levofolinate was carried out. After 2 courses of chemotherapy, metastases of paraaortic lymph nodes and Virchow lymph nodes completely disappeared upon CT examination. Chemotherapy has continued for 14 months, and she is well and has maintained a complete response for more than 1 year. This case suggests that this combination chemotherapy of LV/5-FU, admitted in Japan, is effective against advanced colorectal cancer.

• Authors: Kazuhiko Jingu, Yukihiko Nakajima, Masahito Inoue, Takenori Ochiai
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 31 Issue 1 Pg. 117-9 (Jan 2004) ISSN: 0385-0684 [Print] Japan
• PMID: 14750335 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Leucovorin
• Fluorouracil

Topics

• Adenocarcinoma (drug therapy, secondary)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Drug Administration Schedule
• Female
• Fluorouracil (administration & dosage)
• Humans
• Leucovorin (administration & dosage)
• Lymph Nodes (pathology)
• Lymphatic Metastasis
• Middle Aged
• Rectal Neoplasms (drug therapy, pathology)
• Remission Induction