Solitary fibrous tumor of the cerebellopontine angle with salivary gland heterotopia: a unique presentation.

Abstract

We report the unique association of a solitary fibrous tumor of the cerebellopontine angle with ectopic salivary gland tissue in a 53-year-old woman. The patient, diagnosed 21 years earlier with a right cerebellopontine angle fibrous meningioma, presented with a recurrent mass, which, upon surgical removal, showed features of a solitary fibrous tumor. Strong and diffuse immunoreactivity to CD34 and BCL-2 and a negative epithelial membrane antigen immunostain confirmed the diagnosis. Admixed with the spindle cell neoplasm, a bland glandular element composed of small glands and variably dilated tubules was noted. The vague tubuloacinar arrangement of the glands and the presence of acinar cells with a granular, periodic acid-Schiff-positive, basophilic cytoplasm, resembling serous type acini, were features of benign, although ectopic, salivary gland tissue. The presence of a myoepithelial cell layer, surrounding some of the acini and highlighted by the smooth muscle actin immunostain, strengthened this interpretation.

• Authors: Fausto Rodriguez, Bernd W Scheithauer, Daniel M Ockner, Caterina Giannini
• Journal: The American journal of surgical pathology (Am J Surg Pathol) Vol. 28 Issue 1 Pg. 139-42 (Jan 2004) ISSN: 0147-5185 [Print] United States
• PMID: 14707876 (Publication Type: Case Reports, Journal Article)

Chemical References

• Biomarkers, Tumor

Topics

• Biomarkers, Tumor (analysis)
• Breast Neoplasms (pathology)
• Cerebellar Neoplasms (metabolism, pathology)
• Cerebellopontine Angle (metabolism, pathology)
• Choristoma (metabolism, pathology)
• Female
• Humans
• Immunohistochemistry
• Meningioma (pathology)
• Middle Aged
• Neoplasms, Fibrous Tissue (metabolism, pathology)
• Neoplasms, Multiple Primary (metabolism, pathology)
• Salivary Glands
• Tomography, X-Ray Computed